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Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors

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dc.creatorDEL RÍO-OSPINA, L.spa
dc.creatorLEÓN, S. C. SOTO-DEspa
dc.creatorCAMARGO, M.spa
dc.creatorSÁNCHEZ, R.spa
dc.creatorMORENO-PÉREZ, D. A.spa
dc.creatorPÉREZ-PRADOS, A.spa
dc.creatorPATARROYO, M. E.spa
dc.creatorPATARROYO, M. A.spa
dc.date.accessioned2020-05-26T00:07:04Z
dc.date.available2020-05-26T00:07:04Z
dc.date.created2017spa
dc.description.abstractInvestigating whether high-risk human papillomavirus (HR-HPV) types tend to become grouped in a particular way and whether factors are associated with such grouping is important for measuring the real impact of vaccination. In total, 219 women proving positive for HPV as detected by real-time PCR were included in the study. Each sample was analysed for detecting and quantifying six viral types and the hydroxymethylbilane synthase gene. Multiple correspondence analysis led to determining grouping patterns for six HR-HPV types and simultaneous association with multiple variables and whether viral load was related to the coexistence of other viral types. Two grouping profiles were identified: the first included HPV-16 and HPV-45 and the second profile was represented by HPV-31, HPV-33 and HPV-58. Variables such as origin, contraceptive method, births and pregnancies, educational level, healthcare affiliation regime, atypical squamous cells of undetermined significance and viral load were associated with these grouping profiles. Different socio-demographic characteristics were found when coinfection occurred by phylogenetically related HPV types and when coinfection was due to non-related types. Biological characteristics, the number of viral copies, temporality regarding acquiring infection and competition between viral types could influence the configuration of grouping patterns. Characteristics related to women and HPV, influence such interactions between coexisting HPV types reflecting the importance of their evaluation. Copyright © Cambridge University Press 2017.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1017/S0950268817000188
dc.identifier.issn14694409
dc.identifier.issn09502688
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23957
dc.language.isoengspa
dc.publisherCambridge University Pressspa
dc.relation.citationEndPage1490
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1479
dc.relation.citationTitleEpidemiology and Infection
dc.relation.citationVolumeVol. 145
dc.relation.ispartofEpidemiology and Infection, ISSN:14694409, 09502688, Vol.145, No.7 (2017); pp. 1479-1490spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85012216691&doi=10.1017%2fS0950268817000188&partnerID=40&md5=54f6f3f6f385a800295d66cf958f4670spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordPorphobilinogen deaminasespa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordBirthspa
dc.subject.keywordContraceptionspa
dc.subject.keywordDemographyspa
dc.subject.keywordEducationspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman papillomavirus type 16spa
dc.subject.keywordHuman papillomavirus type 18spa
dc.subject.keywordHuman papillomavirus type 31spa
dc.subject.keywordHuman papillomavirus type 33spa
dc.subject.keywordHuman papillomavirus type 45spa
dc.subject.keywordHuman papillomavirus type 58spa
dc.subject.keywordHydroxymethylbilane synthase genespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPapillomavirus infectionspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPregnancyspa
dc.subject.keywordReal time polymerase chain reactionspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSocial aspectspa
dc.subject.keywordSquamous cellspa
dc.subject.keywordVirus loadspa
dc.subject.keywordAlphapapillomavirusspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordColombiaspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotypespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPapillomavirus infectionsspa
dc.subject.keywordPrevalencespa
dc.subject.keywordVirologyspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdultspa
dc.subject.keywordAlphapapillomavirusspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordColombiaspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPapillomavirus infectionsspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk factorsspa
dc.subject.keywordYoung adultspa
dc.subject.keywordGroupingspa
dc.subject.keywordHigh-risk human papillomavirusspa
dc.subject.keywordMultiple infectionspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordViral dna loadspa
dc.titleMultiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factorsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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