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T-cell activation, alterations in systemic lupus erythematosus: A narrative review

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dc.creatorTéllez Castillo, N.spa
dc.creatorSiachoque Jara, J.J.spa
dc.creatorSiachoque Jara, J.S.spa
dc.creatorSiachoque Jara, M.A.spa
dc.creatorSiachoque Montañez, H.O.spa
dc.date.accessioned2020-05-25T23:59:38Z
dc.date.available2020-05-25T23:59:38Z
dc.date.created2018spa
dc.description.abstractThe activation of T cells is initiated by the presentation of exogenous or endogenous antigens, by antigen presenting cells through the major histocompatibility complex, which binds to a special receptor on T cells. This acknowledgement triggers a cascade of intracellular signalling that leads to an increase in integrin expression, cytoskeletal modifications, and transcription factors production involved in the liberation of cytokines and inflammatory mediators. One of the most important inducers in cell activation is the enzymatic complex with tyrosine kinase action. The kinases which belong to the SRC (SFK) LCK and FYN family have been involved in a large number of important processes in the activation and modulation of the T cells response, as well as in the development of autoimmune diseases. Regulating the kinases signalling, as well as the adapter proteins involved in T cell activation, is essential for maintaining an activation threshold, as well as the modulation of cell response. The phosphorylation of the positive regulation sites of these proteins is important to allow an active configuration of the protein and thereby its maximum capacity as kinase. The phosphorylation of negative regulation sites leads to a closed configuration of the protein that reduces its kinase function, and thereby inhibits its own function. The alteration in signalling by the modification of certain cytoplasmic proteins in some cases is associated with the development of autoimmune diseases, such as systemic lupus erythematosus. Under physiological conditions the T cell receptor complex regroups with protein complexes that interact harmonically to generate an internal signal. The altered signalling events are partly responsible for an anomalous expression of cytokines, including the interleukin-6 (IL-6), IL-10, IL-2, IFN, and CD40 linking, these modifications affects the cells ability to over-stimulate T and B cells, resulting in an increased production of autoantibodies and the triggering of the autoimmune disease. © 2017 Asociación Colombiana de Reumatologíaspa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.rcreu.2017.07.002
dc.identifier.issn01218123
dc.identifier.issn20279000
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23078
dc.language.isospaspa
dc.publisherAsociación Colombiana de Reumatologíaspa
dc.relation.citationEndPage54
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage38
dc.relation.citationTitleRevista Colombiana de Reumatología
dc.relation.citationVolumeVol. 25
dc.relation.ispartofRevista Colombiana de Reumatología, ISSN:01218123, 20279000, Vol.25, No.1 (2018); pp. 38-54spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85044129162&doi=10.1016%2fj.rcreu.2017.07.002&partnerID=40&md5=7523e65d8297745278e6bb0cc31a3a3cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdaptor proteinspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordsrc family tyrosine kinaseeng
dc.subject.keywordMajor histocompatibility antigenspa
dc.subject.keywordProtein tyrosine kinasespa
dc.subject.keywordT lymphocyte receptorspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordAntigen presentationspa
dc.subject.keywordAntigen presenting cellspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordCell functionspa
dc.subject.keywordCell stimulationspa
dc.subject.keywordComplex formationspa
dc.subject.keywordCytokine releasespa
dc.subject.keywordEnzyme activityspa
dc.subject.keywordHumanspa
dc.subject.keywordInflammationspa
dc.subject.keywordIntracellular signalingspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProtein phosphorylationspa
dc.subject.keywordRegulatory mechanismspa
dc.subject.keywordShort surveyspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordT lymphocyte activationspa
dc.subject.keywordFyn proto-oncogeneeng
dc.subject.keywordImmuno receptor tyrosine-based activation motifspa
dc.subject.keywordLeukocyte c-terminal src kinasespa
dc.subject.keywordLinker for activation of t cellspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordT-cell receptorspa
dc.subject.keywordZeta-chain t-cell receptor associated protein kinase 70kdaspa
dc.titleT-cell activation, alterations in systemic lupus erythematosus: A narrative reviewspa
dc.title.TranslatedTitleActivación de la célula T, alteraciones en el lupus eritematoso sistémico, una revisión narrativaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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