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Cerebral autoregulation and activity after propofol for endotracheal intubation in preterm neonates

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dc.creatorThewissen, Liesbethspa
dc.creatorCaicedo Dorado, Alexander
dc.creatorDereymaeker, Anneleenspa
dc.creatorVan Huffel, Sabinespa
dc.creatorNaulaers, Gunnarspa
dc.creatorAllegaert, Karelspa
dc.creatorSmits, Annespa
dc.date.accessioned2020-08-19T14:41:50Z
dc.date.available2020-08-19T14:41:50Z
dc.date.created2018-09-10spa
dc.description.abstractBackground: Despite increasing use of propofol in neonates, observations on cerebral effects are limited. Aim: To investigate cerebral autoregulation (CAR) and activity after propofol for endotracheal intubation in preterm neonates. Methods: Twenty-two neonates received propofol before intubation as part of a published dose-finding study. Mean arterial blood pressure (MABP), near-infrared spectroscopy-derived cerebral oxygenation (rScO2), and amplitude-integrated electroencephalography (aEEG) were analyzed until 180 min after propofol. CAR was expressed as transfer function (TF) gain, indicating % change in rScO2 per 1 mmHg change in MABP. Values exceeding mean TF gain + 2 standard deviations (SD) defined impaired CAR. Results: After intubation with a median propofol dose of 1 (0.5-4.5) mg/kg, rScO2 remained stable during decreasing MABP. Mean (±SD) TF gain was 0.8 (±0.3)%/mmHg. Impaired CAR was identified in 1 and 5 patient(s) during drug-related hypotension and normal to raised MABP, respectively. Suppressed aEEG was observed up to 60 min after propofol. Conclusions: Drug-related hypotension and decreased cerebral activity after intubation with low propofol doses in preterm neonates were observed, without evidence of cerebral ischemic hypoxia. CAR remained intact during drug-related hypotension in 95.5% of patients. Cerebral monitoring including CAR clarifies the cerebral impact of MABP fluctuations.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/s41390-018-0160-3
dc.identifier.issnISSN: 0031-3998
dc.identifier.issnEISSN: 1530-0447
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27349
dc.language.isoengspa
dc.publisherInternational Pediatric Research Foundationspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage725
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage719
dc.relation.citationTitlePediatric Research
dc.relation.citationVolumeVol. 84
dc.relation.ispartofPediatric Research, ISSN: 0031-3998;EISSN: 1530-0447, Vol.84, No.5 (2018); pp.719–725spa
dc.relation.urihttps://www.nature.com/articles/s41390-018-0160-3.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourcePediatric Researchspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordBrain physiologyspa
dc.subject.keywordFemalespa
dc.subject.keywordInfantspa
dc.subject.keywordnewbornspa
dc.subject.keywordInfantspa
dc.subject.keywordprematurespa
dc.titleCerebral autoregulation and activity after propofol for endotracheal intubation in preterm neonatesspa
dc.title.TranslatedTitleAutorregulación cerebral y actividad después de propofol para intubación endotraqueal en neonatos prematurosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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