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A comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombia

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dc.creatorAnaya, Juan-Manuel
dc.creatorRodríguez Velandia, Yhojan Alexis
dc.creatorMonsalve Carmona, Diana Marcela
dc.creatorVega, Daniel
dc.creatorOjeda, Ernesto
dc.creatorGonzalez-Bravo, Diana
dc.creatorRodríguez Jiménez, Mónica María del Pilar
dc.creatorPinto-Díaz, Carlos A.
dc.creatorChaparro, Pablo
dc.creatorGunturiz, María L.
dc.creatorAnsari, Aftab A.
dc.creatorGershwin, M. Eric
dc.creatorMolano González, Nicolás
dc.creatorRamírez Santana, Heily Carolina
dc.creatorAcosta Ampudia, Yeny Yasbleidy
dc.creator.googleAnaya, Juan-Manuelspa
dc.creator.googleRodríguez, Yhojanspa
dc.creator.googleMonsalve, Diana M.spa
dc.creator.googleVega, Danielspa
dc.creator.googleOjeda, Ernestospa
dc.creator.googleGonzalez-Bravo, Dianaspa
dc.creator.googleRodríguez-Jiménez, Mónicaspa
dc.creator.googlePinto-Díaz, Carlos A.spa
dc.creator.googleChaparro, Pablospa
dc.creator.googleGunturiz, María L.spa
dc.creator.googleAnsari, Aftab A.spa
dc.creator.googleGershwin, M. Ericspa
dc.creator.googleMolano-González, Nicolásspa
dc.creator.googleRamírez-Santana, Carolinaspa
dc.creator.googleAcosta-Ampudia, Yenyspa
dc.date.accessioned2018-12-10T22:57:39Z
dc.date.available2018-12-10T22:57:39Z
dc.date.created2017
dc.date.issued2017
dc.description.abstractWe have focused on the epidemiology and immunobiology of Zika virus (ZIKV) infection and factors associated with the development of Guillain-Barré syndrome (GBS) and other neurological syndromes in Cúcuta, the capital of North Santander department, Colombia. Data of patients with ZIKV disease reported to the national population-based surveillance system were used to calculate the basic reproduction number (R0) and the attack rates (ARs) as well as to develop epidemiological maps. Patients with neurological syndromes were contacted and their diagnoses were confirmed. A case-control study in which 29 patients with GBS associated with ZIKV compared with 74-matched control patients with ZIKV infection alone was undertaken. Antibodies against arboviruses and other infections that may trigger GBS were evaluated. The estimated value of R0 ranged between 2.68 (95% CI 2.54–2.67) to 4.57 (95% CI 4.18–5.01). The sex-specific ARs were 1306 per 100,000 females, and 552 per 100,000 males. A non-linear interaction between age and gender on the ARs was observed. The incidence of GBS in Cúcuta increased 4.41 times secondary to ZIKV infection. The lag time between ZIKV infection and neurological symptoms was 7 days (interquartile range 2–14.5). Patients with GBS appeared to represent a lower socioeconomic status and were living near to environmentally contaminated areas. All GBS patients were positive for IgG antibodies against both ZIKV and Dengue virus, and 69% were positive for Chikungunya virus. Noteworthy, GBS was associated with a previous infection with M. pneumoniae (OR: 3.95; 95% CI 1.44–13.01; p = 0.006). No differences in antibody levels against C. jejuni, Epstein-Barr virus and cytomegalovirus were observed. High rates of cranial nerves involvement and dysautonomia were present in 82% and 75.9%, respectively. Intensive care unit (ICU) admission was necessary in 69% of the GBS patients. Most of the patients disclosed a high disability condition (Hughes grade 4). Dysautonomia was the main risk factor of poor GBS prognosis (i.e., ICU admission and disability). Thirteen patients were diagnosed with other neurological syndromes different to GBS (6 with transverse myelitis, 3 with encephalitis, 3 with peripheral facial palsy and one with thoraco-lumbosacral myelopathy). Our data confirm an increased transmission of ZIKV in Cúcuta, and provide support to the view that severe neurological syndromes are related to ZIKV disease. The complex ways by which previous infections and socioeconomic status interact to increase the risk of GBS in people infected by ZIKV should be further investigated. © 2016 The Authorseng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN 0896-8411
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18796
dc.language.isoengspa
dc.relation.citationEndPage138
dc.relation.citationStartPage123
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 77
dc.relation.ispartofJournal of Autoimmunity, ISSN: 0896-8411, Vol. 77 (2017) pp. 123-138spa
dc.relation.urihttps://reader.elsevier.com/reader/sd/pii/S0896841116303122?token=1321E59F163C2BA3FC156B54F4E8B71F9050B60A75C8637E4FC6E45A701F352B1DDA4D00D6C8C101CB63FCB9D4FF56D5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.source.bibliographicCitationChang, C., Ortiz, K., Ansari, A., Gershwin, M.E., The Zika outbreak of the 21st century (2016) J. Autoimmun., 68, pp. 1-13spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectColombiaspa
dc.subjectEpidemiologyspa
dc.subjectGuillain-Barré Syndromespa
dc.subjectMycoplasma Pneumoniaespa
dc.subjectPublic Healthspa
dc.subjectTransverse Myelitisspa
dc.subjectZika Virusspa
dc.subject.decsGanglioside Antibodyspa
dc.subject.decsImmunoglobulin G Antibodyspa
dc.subject.decsImmunoglobulin M Antibodyspa
dc.subject.decsAdultspa
dc.subject.decsArticlespa
dc.subject.decsBasic Reproduction Numberspa
dc.subject.decsCampylobacter Enteritisspa
dc.subject.decsCase Control Studyspa
dc.subject.decsChikungunya Virusspa
dc.subject.decsColombiaspa
dc.subject.decsControlled Studyspa
dc.subject.decsCytomegalovirusspa
dc.subject.decsDengue Virusspa
dc.subject.decsDisabilityspa
dc.subject.decsDisease Severityspa
dc.subject.decsDysautonomiaspa
dc.subject.decsEncephalitisspa
dc.subject.decsEpidemicspa
dc.subject.decsEpstein Barr Virusspa
dc.subject.decsFacial Nerve Paralysisspa
dc.subject.decsFemalespa
dc.subject.decsGuillain Barre Syndromespa
dc.subject.decsHumanspa
dc.subject.decsImmunobiologyspa
dc.subject.decsIntensive Care Unitspa
dc.subject.decsMajor Clinical Studyspa
dc.subject.decsMalespa
dc.subject.decsMyelitisspa
dc.subject.decsPriority Journalspa
dc.subject.decsRetrospective Studyspa
dc.subject.decsRisk Factorspa
dc.subject.decsSocial Statusspa
dc.subject.decsZika Feverspa
dc.subject.decsZika Virusspa
dc.subject.decsAdolescentspa
dc.subject.decsAgespa
dc.subject.decsAgedspa
dc.subject.decsChildspa
dc.subject.decsClinical Trialspa
dc.subject.decsCluster Analysisspa
dc.subject.decsComplicationspa
dc.subject.decsEpidemicspa
dc.subject.decsGuillain Barre Syndromespa
dc.subject.decsHealth Surveyspa
dc.subject.decsImmunologyspa
dc.subject.decsInfantspa
dc.subject.decsMedical Geographyspa
dc.subject.decsMiddle Agedspa
dc.subject.decsMulticenter Studyspa
dc.subject.decsNeurologic Diseasespa
dc.subject.decsOdds Ratiospa
dc.subject.decsPathophysiologyspa
dc.subject.decsPregnancyspa
dc.subject.decsPreschool Childspa
dc.subject.decsSex Differencespa
dc.subject.decsSymptom Assessmentspa
dc.subject.decsTransmissionspa
dc.subject.decsVery Elderlyspa
dc.subject.decsYoung Adultspa
dc.subject.decsZika Feverspa
dc.subject.decsAdolescentspa
dc.subject.decsAdultspa
dc.subject.decsAge Factorsspa
dc.subject.decsAgedspa
dc.subject.decsAged, 8 And Overspa
dc.subject.decsAutoimmune Diseases Of The Nervous Systemspa
dc.subject.decsCase-Control Studiesspa
dc.subject.decsChildspa
dc.subject.decsChild, Preschoolspa
dc.subject.decsCluster Analysisspa
dc.subject.decsColombiaspa
dc.subject.decsDisease Outbreaksspa
dc.subject.decsFemalespa
dc.subject.decsGeography, Medicalspa
dc.subject.decsGuillain-Barre Syndromespa
dc.subject.decsHumansspa
dc.subject.decsInfantspa
dc.subject.decsMalespa
dc.subject.decsMiddle Agedspa
dc.subject.decsOdds Ratiospa
dc.subject.decsPregnancyspa
dc.subject.decsPublic Health Surveillancespa
dc.subject.decsSex Factorsspa
dc.subject.decsSymptom Assessmentspa
dc.subject.decsYoung Adultspa
dc.subject.decsZika Virusspa
dc.subject.decsZika Virus Infectionspa
dc.subject.lembVirus Zikaspa
dc.subject.lembInfección por el virus Zikaspa
dc.subject.lembEpidemiologíaspa
dc.titleA comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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