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Anti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis

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dc.creatorMolano González, Nicolásspa
dc.creatorOlivares-Martínez E.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorHernández-Molina G.spa
dc.date.accessioned2020-05-26T00:00:47Z
dc.date.available2020-05-26T00:00:47Z
dc.date.created2019spa
dc.description.abstractObjective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). Method: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren’s syndrome, Sjögren’s syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody–ACPA. No language restriction was used. Studies were included if they: assessed the association of arthritis and ACPAs, had sufficient data to construct a two-by-two table, tested immunoglobulin G ACPA by any method, and included patients with pSS according to a validated set of classification criteria. We used a random effects model and evaluated the heterogeneity and publication bias. Results: Ten studies were included (involving 1322 patients). We found a pooled odds ratio of 4.42 (95% confidence interval 1.15–16.94, p = 0.03). The test for heterogeneity was I 2  = 0.87. Publication bias was not observed. Based on data from three studies, 33 of 58 pSS patients with ACPAs (57%) developed RA compared with none of 598 pSS patients with negative ACPA (p  and lt; 0.000001). Conclusion: Patients with pSS disclosing ACPAs are prone to arthritis as part of the clinical spectrum of the disease, but are also at risk of developing RA. © 2019, © 2019 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1080/03009742.2018.1469164
dc.identifier.issn15027732
dc.identifier.issn03009742
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23271
dc.language.isoengspa
dc.publisherTaylor and Francis Ltdspa
dc.relation.citationEndPage163
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage157
dc.relation.citationTitleScandinavian Journal of Rheumatology
dc.relation.citationVolumeVol. 48
dc.relation.ispartofScandinavian Journal of Rheumatology, ISSN:15027732, 03009742, Vol.48, No.2 (2019); pp. 157-163spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054341329&doi=10.1080%2f03009742.2018.1469164&partnerID=40&md5=d83ddd2de37c041cdffa7c262c17ba42spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCyclic citrullinated peptide antibodyspa
dc.subject.keywordrheumatoideng
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordCyclic citrullinated peptide antibodyspa
dc.subject.keywordArthritisspa
dc.subject.keywordArthropathyspa
dc.subject.keywordArticlespa
dc.subject.keywordCochrane libraryspa
dc.subject.keywordHumanspa
dc.subject.keywordMedlinespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSynovitisspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordWeb of sciencespa
dc.subject.keywordComplicationspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMeta analysisspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordAnti-citrullinated protein antibodiesspa
dc.subject.keywordArthritiseng
dc.subject.keywordHumansspa
dc.subject.keywordSjogren's syndromespa
dc.titleAnti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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