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Autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA)--animal models as a proof of concept

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dc.creatorCruz Tapias, Paolaspa
dc.creatorAgmon Levin, Nancyspa
dc.creatorIsraeli, Eitanspa
dc.creatorAnaya, Juan-Manuel
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-08-28T15:48:12Z
dc.date.available2020-08-28T15:48:12Z
dc.date.created2013-10-01spa
dc.description.abstractASIA syndrome, “Autoimmune (Auto-inflammatory) Syndromes Induced by Adjuvants” includes at least four conditions which share a similar complex of signs and symptoms and have been defined by hyperactive immune responses: siliconosis, macrophagic myofasciitis syndrome, Gulf war syndrome and post-vaccination phenomena. Exposure to adjuvants has been documented in these four medical conditions, suggesting that the common denominator to these syndromes is a trigger entailing adjuvant activity. An important role of animal models in proving the ASIA concept has been established. Experimentally animal models of autoimmune diseases induced by adjuvants are currently widely used to understand the mechanisms and etiology and pathogenesis of these diseases and might thus promote the development of new diagnostic, predictive and therapeutic methods. In the current review we wish to unveil the variety of ASIA animal models associated with systemic and organ specific autoimmune diseases induced by adjuvants. We included in this review animal models for rheumatoid arthritis-like disease, for systemic lupus erythematosus-like disease, autoimmune thyroid disease-like disease, antiphospholipid syndrome, myocarditis and others. All these models support the concept of ASIA, as the Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN : 0929-8673
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28440
dc.language.isoengspa
dc.publisherBethamsciencespa
dc.relation.citationEndPage4036
dc.relation.citationIssueNo. 32
dc.relation.citationStartPage4030
dc.relation.citationTitleCurrent Medicinal Chemistry
dc.relation.citationVolumeVol. 20
dc.relation.ispartofAutoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants (ASIA) – Animal Models as a Proof of Concept, ISSN : 0929-8673, Vol. 20, No. 32 (2013); pp. 4030-4036spa
dc.relation.urihttps://www.ingentaconnect.com/content/ben/cmc/2013/00000020/00000032/art00003spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceCurrent Medicinal Chemistryspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordASIAspa
dc.subject.keywordAutoimmune syndromespa
dc.subject.keywordAdjuvantsspa
dc.subject.keywordAnimal modelseng
dc.subject.keywordAutoinflammatory syndromespa
dc.titleAutoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA)--animal models as a proof of conceptspa
dc.title.TranslatedTitleSíndrome autoinmune (autoinflamatorio) inducido por adyuvantes (ASIA): modelos animales como prueba de conceptospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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