Ítem
Solo Metadatos

alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.

Mostrar el registro sencillo de la publicación
dc.creatorSuárez, C. F.spa
dc.creatorCárdenas, P. P.spa
dc.creatorLlanos-Ballestas, E. J.spa
dc.creatorMart?ínez, P.spa
dc.creatorObregon, M.spa
dc.creatorPatarroyo, M. A.spa
dc.date.accessioned2020-08-06T16:21:03Z
dc.date.available2020-08-06T16:21:03Z
dc.date.created2013-05-12spa
dc.description.abstractFunctional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps and A. vociferans). We found 24 sequences, which divided into two different groups (Ao-g1 and Ao-g2). A further sequence was identified as a processed pseudogene (Aona-PS2). Both sequence evolution and variability analyses showed that Ao-g1 and Ao-g2 display similar characteristics to Catarrhini’s classical loci, such as positive selection pressure at the peptide binding region (PBR) high variability and a trans-specific evolution pattern.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1034/j.1399-0039.2003.00045.x
dc.identifier.issnEISSN: 2059-2310
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26236
dc.language.isoengspa
dc.publisherThe HLA Awardspa
dc.publisherJohn Wiley & Sonsspa
dc.relation.citationEndPage373
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage362
dc.relation.citationTitleHLA. Tissue Antigens
dc.relation.citationVolumeVol. 61
dc.relation.ispartofHLA.Tissue Antigens, EISSN:2059-2310, Vol.61, No.5 (May, 2003) pp 362-373spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1034/j.1399-0039.2003.00045.xspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceHLA. Tissue Antigensspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAnimal modelsspa
dc.subject.keywordAotusspa
dc.subject.keywordEvolutionspa
dc.subject.keywordMHC class Ispa
dc.subject.keywordPBRspa
dc.subject.keywordPlatyrrhinispa
dc.titlealpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.spa
dc.title.TranslatedTitleLos dominios alpha1 y alpha2 de Aotus MHC Clase I y Catarrhini MHC Clase Ia comparten características similares.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos