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High mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala

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dc.creatorSamayoa, Blancaspa
dc.creatorRoy, Monikaspa
dc.creatorCleveland, Angela Ahlquistspa
dc.creatorMedina, Nardaspa
dc.creatorLau-Bonilla, Daliaspa
dc.creatorScheel, Christina Mspa
dc.creatorGómez Giraldo, Beatríz Lucía
dc.creatorChiller, Tomspa
dc.creatorArathoon, Eduardospa
dc.date.accessioned2020-05-26T00:10:06Z
dc.date.available2020-05-26T00:10:06Z
dc.date.created2017spa
dc.description.abstractHistoplasmosis is one of the most common and deadly opportunistic infections among persons living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome in Latin America, but due to limited diagnostic capacity in this region, few data on the burden and clinical characteristics of this disease exist. Between 2005 and 2009, we enrolled patients 18 years of age with suspected histoplasmosis at a hospital-based HIV clinic in Guatemala City. A case of suspected histoplasmosis was defined as a person presenting with at least three of five clinical or radiologic criteria. A confirmed case of histoplasmosis was defined as a person with a positive culture or urine antigen test for Histoplasma capsulatum. Demographic and clinical data were also collected and analyzed. Of 263 enrolled as suspected cases of histoplasmosis, 101 (38.4%) were confirmed cases. Median time to diagnosis was 15 days after presentation (interquartile range [IQR] = 5-23). Crude overall mortality was 43.6%; median survival time was 19 days (IQR = 4-69). Mycobacterial infection was diagnosed in 70 (26.6%) cases; 26 (25.7%) histoplasmosis cases were coinfected with mycobacteria. High mortality and short survival time after initial symptoms were observed in patients with histoplasmosis. Mycobacterial coinfection diagnoses were frequent, highlighting the importance of pursuing diagnoses for both diseases. and copy; 2017 by The American Society of Tropical Medicine and Hygiene.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4269/ajtmh.16-0009
dc.identifier.issn29637
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24207
dc.language.isoengspa
dc.publisherAmerican Society of Tropical Medicine and Hygienespa
dc.relation.citationEndPage48
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage42
dc.relation.citationTitleAmerican Journal of Tropical Medicine and Hygiene
dc.relation.citationVolumeVol. 97
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene, ISSN:29637, Vol.97, No.1 (2017); pp. 42-48spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85024380336&doi=10.4269%2fajtmh.16-0009&partnerID=40&md5=2dc7d29c2ef770c16950ed188f08f1ffspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmphotericin Bspa
dc.subject.keywordAntiretrovirus agentspa
dc.subject.keywordFluconazolespa
dc.subject.keywordItraconazolespa
dc.subject.keywordAcquired immune deficiency syndromespa
dc.subject.keywordAjellomyces capsulatusspa
dc.subject.keywordAntifungal therapyspa
dc.subject.keywordAntiretroviral therapyspa
dc.subject.keywordArticlespa
dc.subject.keywordClinical featurespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordGuatemalaspa
dc.subject.keywordHistoplasmosisspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordInfection sensitivityspa
dc.subject.keywordMedian survival timespa
dc.subject.keywordMedical historyspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordMortalityspa
dc.subject.keywordMycobacteriosisspa
dc.subject.keywordProspective studyspa
dc.subject.keywordAcquired immune deficiency syndromespa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAIDS related complexspa
dc.subject.keywordCause of deathspa
dc.subject.keywordComplicationspa
dc.subject.keywordFemalespa
dc.subject.keywordHistoplasmaspa
dc.subject.keywordHistoplasmosisspa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordIsolation and purificationspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordMortalityspa
dc.subject.keywordSurvivalspa
dc.subject.keywordVery elderlyspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAcquired Immunodeficiency Syndromespa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordAIDS-Related Opportunistic Infectionsspa
dc.subject.keywordCause of Deathspa
dc.subject.keywordCohort Studiesspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordFemalespa
dc.subject.keywordGuatemalaspa
dc.subject.keywordHistoplasmaspa
dc.subject.keywordHistoplasmosisspa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordMortalityspa
dc.subject.keywordProspective Studiesspa
dc.subject.keywordSurvivalspa
dc.subject.keywordYoung Adultspa
dc.titleHigh mortality and coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemalaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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