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Clinical and histopathological characterization of children with autoimmune hepatitis at a referral center in bogotá, colombia

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dc.creatorSuárez D.spa
dc.creatorAndrade R.spa
dc.creatorVera J.F.spa
dc.creatorLópez-Panqueva R.P.spa
dc.date.accessioned2020-05-25T23:59:22Z
dc.date.available2020-05-25T23:59:22Z
dc.date.created2019spa
dc.description.abstractAutoimmune hepatitis (AIH) is a progressive inflammatory liver disease. It is uncommon in children and adolescents, and is a diagnostic challenge for clinicians and pathologists. We describe the clinical, biochemical and histopathological characteristics of 21 pediatric patients with AIH diagnosed in the last 14 years. Liver biopsies were reassessed to analyze histopathological findings in detail. Of the 21 cases evaluated, 12 (57.1%) were girls and young women, the median age was 14 years old, and 17 (80.9%) had type 1 AIH. The most frequent clinical signs were jaundice (66.7%), choluria (44.4%), evidence of portal hypertension with esophageal varices (47.1%), and splenomegaly (41.2%). Histories of other autoimmune diseases were found in 11.8% of these patients. Elevated levels of aminotransferases were found in 89.5% of the patients, hyperbilirubinemia was found in 88.9%, and 60.0% of the cases had low levels of serum albumin. Reassessed biopsies showed portal lymphoplasmocytic infiltrate (94.4%), interface hepatitis (77.8%) and rosette formation (50.0%). Hyaline inclusions were found in Kupffer cells in 42.9% of the biopsies. About 33.5% of the cases showed cirrhosis at the initial biopsy. Despite immunosuppressive treatment, four patients required liver transplantation and two are on the waiting list. AIH in children can manifest with jaundice, choluria, signs of portal hypertension, elevated aminotransferases, hyperbilirubinemia and circulating antibodies. Hyaline inclusions in Kupffer cells may be a useful finding in the histopathological diagnosis of AIH in children. © 2019 Asociaciones Colombianas de Gastroenterología, Endoscopia digestiva, Coloproctología y Hepatología.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.22516/25007440.346
dc.identifier.issn1209957
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23032
dc.language.isoengspa
dc.publisherAsociacion Colombiana de Gastroenterologiaspa
dc.relation.citationEndPage369
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage364
dc.relation.citationTitleRevista Colombiana de Gastroenterologia
dc.relation.citationVolumeVol. 34
dc.relation.ispartofRevista Colombiana de Gastroenterologia, ISSN:1209957, Vol.34, No.4 (2019); pp. 364-369spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85079541655&doi=10.22516%2f25007440.346&partnerID=40&md5=3979b279bc91f1c371856640b81da39espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordBiopsyspa
dc.subject.keywordChildspa
dc.subject.keywordPathologyspa
dc.titleClinical and histopathological characterization of children with autoimmune hepatitis at a referral center in bogotá, colombiaspa
dc.title.TranslatedTitleCaracterización clínica e histopatológica de niños con hepatitis autoinmune en un centro de referencia de bogotá, colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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