Ítem
Solo Metadatos

Noninvasive vaccination against infectious diseases

Mostrar el registro sencillo de la publicación
dc.creatorZheng, Zhichaospa
dc.creatorDíaz Arévalo, Diana
dc.creatorGuan, Hongbingspa
dc.creatorZeng, Mingtaospa
dc.date.accessioned2020-05-26T00:10:30Z
dc.date.available2020-05-26T00:10:30Z
dc.date.created2018spa
dc.description.abstractThe development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effective in humans there are some issues that should be considered, such as the adjuvant, the route of vaccination, and the antigen-carrier system. While almost all licensed vaccines are injected such that inoculation is by far the most commonly used method, injection has several potential disadvantages, including pain, cross contamination, needlestick injury, under- or overdosing, and increased cost. It is also problematic for patients from rural areas of developing countries, who must travel to a hospital for vaccine administration. Noninvasive immunizations, including oral, intranasal, and transcutaneous administration of vaccines, can reduce or eliminate pain, reduce the cost of vaccinations, and increase their safety. Several preclinical and clinical studies as well as experience with licensed vaccines have demonstrated that noninvasive vaccine immunization activates cellular and humoral immunity, which protect against pathogen infections. Here we review the development of noninvasive immunization with vaccines based on live attenuated virus, recombinant adenovirus, inactivated virus, viral subunits, virus-like particles, DNA, RNA, and antigen expression in rice in preclinical and clinical studies. We predict that noninvasive vaccine administration will be more widely applied in the clinic in the near future. © 2018, © 2018 The Author(s). Published with license by Taylor and Francis. © 2018, © Zhichao Zheng, Diana Diaz-Arévalo, Hongbing Guan, and Mingtao Zeng.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1080/21645515.2018.1461296
dc.identifier.issn21645515
dc.identifier.issn2164554X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24232
dc.language.isoengspa
dc.publisherTaylor and Francis Inc.spa
dc.relation.citationEndPage1733
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1717
dc.relation.citationTitleHuman Vaccines and Immunotherapeutics
dc.relation.citationVolumeVol. 14
dc.relation.ispartofHuman Vaccines and Immunotherapeutics, ISSN:21645515, 2164554X, Vol.14, No.7 (2018); pp. 1717-1733spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85050392932&doi=10.1080%2f21645515.2018.1461296&partnerID=40&md5=ddd35f65f6aa9d045a093490fec1617dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordVaccinespa
dc.subject.keywordcellulareng
dc.subject.keywordVirus vaccinespa
dc.subject.keywordAntigen expressionspa
dc.subject.keywordClinical trial (topic)spa
dc.subject.keywordDna rna hybridizationspa
dc.subject.keywordDrug safetyspa
dc.subject.keywordHumoral immunityspa
dc.subject.keywordImmunizationspa
dc.subject.keywordInfectionspa
dc.subject.keywordLicencespa
dc.subject.keywordNon invasive procedurespa
dc.subject.keywordReviewspa
dc.subject.keywordSafety procedurespa
dc.subject.keywordVaccinationspa
dc.subject.keywordVirus inactivationspa
dc.subject.keywordVirus like agentspa
dc.subject.keywordAnimalspa
dc.subject.keywordCellular immunityspa
dc.subject.keywordCommunicable disease controlspa
dc.subject.keywordCutaneous drug administrationspa
dc.subject.keywordDeveloping countryspa
dc.subject.keywordEconomicsspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHospitalspa
dc.subject.keywordHumanspa
dc.subject.keywordHumoral immunityspa
dc.subject.keywordImmunologyspa
dc.subject.keywordIntranasal drug administrationspa
dc.subject.keywordMousespa
dc.subject.keywordProceduresspa
dc.subject.keywordVaccinationspa
dc.subject.keywordVirus infectionspa
dc.subject.keywordAdjuvantseng
dc.subject.keywordAdministrationeng
dc.subject.keywordAdministrationeng
dc.subject.keywordAnimalsspa
dc.subject.keywordClinical trials as topicspa
dc.subject.keywordCommunicable disease controlspa
dc.subject.keywordDeveloping countriesspa
dc.subject.keywordHospitalsspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunityeng
dc.subject.keywordImmunityeng
dc.subject.keywordMicespa
dc.subject.keywordVaccinationspa
dc.subject.keywordViral vaccinesspa
dc.subject.keywordVirus diseasesspa
dc.subject.keywordBacteriaspa
dc.subject.keywordClinical trialspa
dc.subject.keywordInfectious diseasespa
dc.subject.keywordIntranasalspa
dc.subject.keywordMicroneedlespa
dc.subject.keywordNoninvasivespa
dc.subject.keywordOralspa
dc.subject.keywordTranscutaneousspa
dc.subject.keywordVaccinespa
dc.subject.keywordVirusspa
dc.titleNoninvasive vaccination against infectious diseasesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos