Ítem
Solo Metadatos

The use of hemodynamic and cerebral monitoring to study pharmacodynamics in neonates

Mostrar el registro sencillo de la publicación
dc.creatorSmits, A.spa
dc.creatorThewissen, L.spa
dc.creatorDereymaeker, A.spa
dc.creatorDempsey, E.spa
dc.creatorCaicedo, A.spa
dc.creatorNaulaers, G.spa
dc.date.accessioned2020-08-19T14:41:01Z
dc.date.available2020-08-19T14:41:01Z
dc.date.created2017spa
dc.description.abstractBackground: Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates. Methods: We aim to provide an overview of the frequently used monitoring tools to assess drug effects on the hemodynamic status as well as the cerebral circulation, oxygenation and cerebral metabolism in neonates. Results: The use of blood pressure measurements, heart rate variability, functional echocardiography, nearinfrared spectroscopy and (amplitude-integrated) electroencephalography in neonates is discussed, as well as new parameters introduced by these tools. Based on the ‘brain circulation model’, the hemodynamic effects on the brain and their interplay are summarized. In this model, 3 processes (i.e. blood processes, vascular smooth muscle processes and tissue processes) and 3 mechanisms (i.e. autoregulation, blood flow metabolism coupling and cerebral oxygen balance) are distinguished, which all may be influenced by drug administration. Finally, propofol, sevoflurane, midazolam and inotropes are used as examples of which PD has been studied using the available hemodynamic and/or cerebral monitoring tools. Conclusion: The implementation of (non-)invasive monitoring tools to document hemodynamic and cerebral PD effects in neonates is of relevance both in a neonatal research and intensive clinical care setting. We highlight the need to integrate these tools in future PD research. Furthermore, besides short-term drug effects, long-term outcome of drug therapy in neonates also warrants further attention.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1381612823666170918124419
dc.identifier.issnISSN: 1381-6128
dc.identifier.issnEISSN: 1873-4286
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27107
dc.language.isoengspa
dc.publisherBentham Science Publishersspa
dc.relation.citationEndPage5963
dc.relation.citationIssueNo. 38
dc.relation.citationStartPage5955
dc.relation.citationTitleCurrent Pharmaceutical Design
dc.relation.citationVolumeVol. 23
dc.relation.ispartofCurrent Pharmaceutical Design, ISSN: 1381-6128;EISSN: 1873-4286, Vol.23, No.38 (2017); pp. 5955-5963 spa
dc.relation.urihttps://www.eurekaselect.com/155663/articlespa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceCurrent Pharmaceutical Designspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPharmacodynamicsspa
dc.subject.keywordNeonatespa
dc.subject.keywordMonitoringspa
dc.subject.keywordHemodynamicsspa
dc.subject.keywordCerebral activityspa
dc.subject.keywordCentral nervous systemspa
dc.titleThe use of hemodynamic and cerebral monitoring to study pharmacodynamics in neonatesspa
dc.title.TranslatedTitleEl uso de monitorización hemodinámica y cerebral para estudiar la farmacodinámica en recién nacidosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos