Ítem
Solo Metadatos

Human myeloid dendritic cells treated with supernatants of rotavirus infected Caco-2 cells induce a poor Th1 response

Mostrar el registro sencillo de la publicación
dc.creatorRodríguez, Luz-Stellaspa
dc.creatorNarváez, Carlos F.spa
dc.creatorRojas, Olga L.spa
dc.creatorFranco, Manuel A.spa
dc.creatorÁngel, Juanaspa
dc.date.accessioned2020-05-26T00:03:59Z
dc.date.available2020-05-26T00:03:59Z
dc.date.created2012spa
dc.description.abstractWe have previously shown that human myeloid dendritic cells treated with purified rotavirus induce an allogenic Th1 response. To determine if rotavirus in the context of an intestinal microenvironment modulates the function of dendritic cells, we treated these cells with supernatants from non-infected or infected Caco-2 cells and studied their capacity to promote Th1 or Th2 responses. Dendritic cells treated with supernatants from rotavirus-infected Caco-2 cells promoted a significantly lower Th1 response, in comparison with those treated with purified rotavirus. We wanted to establish if TGF-?1, induced, or TSLP, not induced, during rotavirus infection, could mediate this effect. Neutralization of TGF-? but not TSLP in the supernatant prior to treatment of dendritic cells increased their capacity to promote a Th1 response. The results suggest that the TGF-?1 induced by rotavirus could be an immune evasion mechanism, and may partially explain the poor rotavirus-specific T cell response we have previously evidenced. © 2011 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cellimm.2011.10.017
dc.identifier.issn10902163
dc.identifier.issn00088749
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23645
dc.language.isoengspa
dc.relation.citationEndPage161
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage154
dc.relation.citationTitleCellular Immunology
dc.relation.citationVolumeVol. 272
dc.relation.ispartofCellular Immunology, ISSN:10902163, 00088749, Vol.272, No.2 (2012); pp. 154-161spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-83955162315&doi=10.1016%2fj.cellimm.2011.10.017&partnerID=40&md5=58bdd1bac891d261c944f047569ac98bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordThymic stromal lymphopoietinspa
dc.subject.keywordcd86eng
dc.subject.keywordArticlespa
dc.subject.keywordCell strain caco 2spa
dc.subject.keywordCellular immunityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCytokine productionspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordImmunomodulationspa
dc.subject.keywordIntestine mucosaspa
dc.subject.keywordMyeloid dendritic cellspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRotavirus infectionspa
dc.subject.keywordSupernatantspa
dc.subject.keywordTh1 cellspa
dc.subject.keywordTh2 cellspa
dc.subject.keywordVirus neutralizationspa
dc.subject.keywordAntigenseng
dc.subject.keywordCaco-2 cellsspa
dc.subject.keywordCd4-positive t-lymphocytesspa
dc.subject.keywordCellular microenvironmentspa
dc.subject.keywordCoculture techniquesspa
dc.subject.keywordCytokinesspa
dc.subject.keywordDendritic cellsspa
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunologic factorsspa
dc.subject.keywordMyeloid cellsspa
dc.subject.keywordRnaeng
dc.subject.keywordRotavirusspa
dc.subject.keywordRotavirus infectionsspa
dc.subject.keywordTh1 cellsspa
dc.subject.keywordTh2 cellsspa
dc.subject.keywordTransforming growth factor beta1spa
dc.subject.keywordTumor cellseng
dc.subject.keywordRotavirusspa
dc.subject.keywordCaco-2 cellsspa
dc.subject.keywordDendritic cellsspa
dc.subject.keywordImmunomodulatorsspa
dc.subject.keywordRotavirusspa
dc.subject.keywordTgf-?1spa
dc.titleHuman myeloid dendritic cells treated with supernatants of rotavirus infected Caco-2 cells induce a poor Th1 responsespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos