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The autoimmune ecology

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorAlzate, Maria A.spa
dc.creatorMolano González, Nicolás
dc.creatorRojas-Villarraga, Adriana
dc.date.accessioned2020-05-26T00:08:30Z
dc.date.available2020-05-26T00:08:30Z
dc.date.created2016spa
dc.description.abstractAutoimmune diseases (ADs) represent a heterogeneous group of disorders that affect specific target organs or multiple organ systems. These conditions share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities they have among them as well as their familial clustering (i.e., coaggregation). As part of the autoimmune tautology, the influence of environmental exposure on the risk of developing ADs is paramount (i.e., the autoimmune ecology). In fact, environment, more than genetics, shapes immune system. Autoimmune ecology is akin to exposome, that is all the exposures - internal and external - across the lifespan, interacting with hereditary factors (both genetics and epigenetics) to favor or protect against autoimmunity and its outcomes. Herein, we provide an overview of the autoimmune ecology, focusing on the immune response to environmental agents in general, and microbiota, cigarette smoking, alcohol and coffee consumption, socioeconomic status (SES), gender and sex hormones, vitamin D, organic solvents, and vaccines in particular. Inclusion of the autoimmune ecology in disease etiology and health will improve the way personalized medicine is currently conceived and applied. © 2016 Anaya, Ramirez-Santana, Alzate, Molano-Gonzalez and Rojas-Villarraga.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fimmu.2016.00139
dc.identifier.issn16643224
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24089
dc.language.isoengspa
dc.publisherFrontiers Media S.A.spa
dc.relation.citationIssueNo. APR
dc.relation.citationTitleFrontiers in Immunology
dc.relation.citationVolumeVol. 7
dc.relation.ispartofFrontiers in Immunology, ISSN:16643224, Vol.7, No.APR (2016)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84966716018&doi=10.3389%2ffimmu.2016.00139&partnerID=40&md5=bf03faa579e46cfcd9946d96592fd883spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keyword2,3,7,8 tetrachlorodibenzo para dioxinspa
dc.subject.keywordAlcoholspa
dc.subject.keywordB cell activating factorspa
dc.subject.keywordHigh mobility group b1 proteinspa
dc.subject.keywordImmunoglobulin enhancer binding proteinspa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordInterleukin 1spa
dc.subject.keywordInterleukin 2spa
dc.subject.keywordInterleukin 23spa
dc.subject.keywordInterleukin 27spa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordInterleukin 8spa
dc.subject.keywordOrganic solventspa
dc.subject.keywordProstaglandinspa
dc.subject.keywordSex hormonespa
dc.subject.keywordToll like receptorspa
dc.subject.keywordToll like receptor 1spa
dc.subject.keywordToll like receptor 2spa
dc.subject.keywordToll like receptor 3spa
dc.subject.keywordToll like receptor 4spa
dc.subject.keywordToll like receptor 5spa
dc.subject.keywordToll like receptor 6spa
dc.subject.keywordToll like receptor 7spa
dc.subject.keywordToll like receptor 8spa
dc.subject.keywordToll like receptor 9spa
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordVaccinespa
dc.subject.keywordVitamin dspa
dc.subject.keywordAlcohol consumptionspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordB lymphocyte activationspa
dc.subject.keywordClinical trial (topic)spa
dc.subject.keywordCoffeespa
dc.subject.keywordDisease coursespa
dc.subject.keywordDna methylationspa
dc.subject.keywordEcologyspa
dc.subject.keywordEnvironmental exposurespa
dc.subject.keywordEnvironmental factorspa
dc.subject.keywordGenderspa
dc.subject.keywordGene expressionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordInfectionspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordMeta analysis (topic)spa
dc.subject.keywordMicrofloraspa
dc.subject.keywordNonhumanspa
dc.subject.keywordRandomized controlled trial (topic)spa
dc.subject.keywordReviewspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSmokingspa
dc.subject.keywordSocial statusspa
dc.subject.keywordSystematic review (topic)spa
dc.subject.keywordT lymphocytespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordEcologyspa
dc.subject.keywordEnvironmentspa
dc.subject.keywordPersonalized medicinespa
dc.subject.keywordPolyautoimmunityspa
dc.titleThe autoimmune ecologyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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