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Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study

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dc.creatorHawi, Zspa
dc.creatorCummins, T D Rspa
dc.creatorTong, Jspa
dc.creatorArcos-Burgos, Mspa
dc.creatorZhao, Qspa
dc.creatorMatthews, Nspa
dc.creatorNewman, D Pspa
dc.creatorJohnson, Bspa
dc.creatorVance, Aspa
dc.creatorHeussler, H Sspa
dc.creatorLevy, Fspa
dc.creatorEasteal, Sspa
dc.creatorWray, N Rspa
dc.creatorKenny, Espa
dc.creatorMorris, Dspa
dc.creatorKent, Lspa
dc.creatorGill, Mspa
dc.creatorBellgrove, M Aspa
dc.date.accessioned2020-08-19T14:40:22Z
dc.date.available2020-08-19T14:40:22Z
dc.date.created2016-07-26spa
dc.description.abstractAttention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (<1% frequency) single-nucleotide variants (SNVs) revealed that the gene encoding brain-derived neurotrophic factor (BDNF) was associated with ADHD at Bonferroni corrected levels. Sanger sequencing confirmed the existence of all novel rare BDNF variants. Our results implicate BDNF as a genetic risk factor for ADHD, potentially by virtue of its critical role in neurodevelopment and synaptic plasticity.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/mp.2016.117
dc.identifier.issnISSN: 1359-4184
dc.identifier.issnEISSN: 1476-5578
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26846
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage584
dc.relation.citationStartPage580
dc.relation.citationTitleMolecular Psychiatry
dc.relation.citationVolumeVol. 22
dc.relation.ispartofMolecular Psychiatry, ISSN: 1359-4184;EISSN: 1476-5578, Vol.22 (2017); pp. 580–584spa
dc.relation.urihttps://www.nature.com/articles/mp2016117spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceMolecular Psychiatryspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordADHDspa
dc.subject.keywordGeneticsspa
dc.titleRare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing studyspa
dc.title.TranslatedTitleVariantes raras de ADN en el gen del factor neurotrófico derivado del cerebro aumentan el riesgo de trastorno por déficit de atención con hiperactividad: un estudio de secuenciación de próxima generaciónspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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