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Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia

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dc.creatorLeón, Cielo M.
dc.creatorHernández, Carolina
dc.creatorMontilla, Marleny
dc.creatorRamírez, Juan David
dc.creator.googleLeón, Cielo Mspa
dc.creator.googleHernández, Carolinaspa
dc.creator.googleMontilla, Marlenyspa
dc.creator.googleRamírez, Juan Davidspa
dc.date.accessioned2020-04-15T21:55:58Z
dc.date.available2020-04-15T21:55:58Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractTrypanosoma cruzi is the aetiological agent of Chagas disease, which affects approximately eight million people in the Americas. This parasite exhibits genetic variability, with at least six discrete typing units broadly distributed in the American continent. T. cruzi I (TcI) shows remarkable genetic diversity; a genotype linked to human infections and a domestic cycle of transmission have recently been identified, hence, this strain was named TcIDom. The aim of this work was to describe the spatiotemporal distribution of TcI subpopulations across humans, insect vectors and mammalian reservoirs in Colombia by means of molecular typing targeting the spliced leader intergenic region of mini-exon gene. We analysed 101 TcI isolates and observed a distribution of sylvatic TcI in 70% and TcIDom in 30%. In humans, the ratio was sylvatic TcI in 60% and TcIDom in 40%. In mammal reservoirs, the distribution corresponded to sylvatic TcI in 96% and TcIDom in 4%. Among insect vectors, sylvatic TcI was observed in 48% and TcIDom in 52%. In conclusion, the circulation of TcIDom is emerging in Colombia and this genotype is still adapting to the domestic cycle of transmission. The epidemiological and clinical implications of these findings are discussed herein. © 2015, Fundacao Oswaldo Cruz. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1590/0074-02760140402
dc.identifier.issn0074-0276
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21640
dc.language.isoengspa
dc.relation.citationEndPage393
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage387
dc.relation.citationTitleMemorias do Instituto Oswaldo Cruz
dc.relation.citationVolumeVol. 110
dc.relation.ispartofMemorias do Instituto Oswaldo Cruz, ISSN: 0074-0276 Vol. 110, No. 3 (2015) pp. 387-393spa
dc.relation.urihttp://www.scielo.br/pdf/mioc/v110n3/0074-0276-mioc-0074-02760140402.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectEnfermedad de Chagasspa
dc.subjectGenotiposspa
dc.subjectCiclo domésticospa
dc.subjectCiclo selváticospa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordGenotypesspa
dc.subject.keywordDomestica cyclespa
dc.subject.keywordSylvatic cyclespa
dc.subject.lembTrypanosoma cruzispa
dc.subject.lembEnfermedad de chagasspa
dc.titleRetrospective distribution of Trypanosoma cruzi I genotypes in Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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