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Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis

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dc.creatorGarcia-Perdomo, Herney
dc.creatorJiménez Mejías, Eladio
dc.creatorLOPEZ RAMOS, HUGO ENRIQUE
dc.creator.googleGarcía-Perdomo, Herney Andrésspa
dc.creator.googleJiménez-Mejías, Eladiospa
dc.creator.googleLópez-Ramos, Hugospa
dc.date.accessioned2020-04-17T16:00:22Z
dc.date.available2020-04-17T16:00:22Z
dc.date.created2015-06
dc.date.issued2015
dc.description.abstractObjective: To estimate the efficacy of antibiotic prophylaxis to prevent urinary tract infection in patients (both gender) who undergo a cystoscopy with sterile urine. Materials and Methods: Search strategy (January 1980-December 2013) in Medline via PubMed, CENTRAL, and EMBASE. Additionally, we searched databases for registered trials and conference abstracts, as well as reference lists of systematic reviews and included studies. Seven published randomized clinical trials (January 1, 1980 to December 31, 2013) were included in quantitative analyses with no language restrictions. Two independent reviewers collected data. Risk of bias was evaluated with the Cochrane Collaboration tool. We performed a fixed effect analyses due to statistical homogeneity. The primary outcome was urinary tract infection and the secondary was asymptomatic bacteriuria. The effect measure was the risk difference (RD) with 95% confidence interval. The planned interventions were: Antibiotic vs placebo; Antibiotic vs no intervention and Antibiotic vs any other intervention. Results: 3038 patients were found in seven studies. For the primary outcome, we included 5 studies and we found a RR 0.53 CI95% (0.31, 0.90) and a RD-0.012 CI95% (-0.023,-0.002), favoring antibiotic prophylaxis. For asymptomatic bacteriuria we included 6 studies and we found a RR 0.28 CI95% (0.20, 0.39) and a RD-0.055 CI95% (-0.07,-0.039), was found favoring prophylaxis. According to GRADE evaluation, we considered moderate quality of evidence for both outcomes. The subgroup analysis showed that only two studies were classified as having low risk of bias: Cam 2009 and García-Perdomo 2013. They showed no statistical differences (RD-0.009 CI95% -0.03, 0.011). Conclusions: Based on studies classified as low risk of bias, we found moderate evidence to not recommend the use of antibiotic prophylaxis to prevent urinary tract infection and asymptomatic bacteriuria in patients who undergo cystoscopy with sterile urine in an ambulatory setting.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1590/S1677-5538.IBJU.2014.0198
dc.identifier.issn1677-5538
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21661
dc.language.isoengspa
dc.relation.citationEndPage422
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage412
dc.relation.citationTitleInternational Braz J Urol
dc.relation.citationVolumeVol. 41
dc.relation.ispartofInternational Braz J Urol, ISSN: 1677-5538 Vol. 41, No. 3 (2015) pp. 412-422spa
dc.relation.urihttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000300412spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectRandomized Controlled Trials as Topicspa
dc.subjectInfección urinariaspa
dc.subjectMeta análisisspa
dc.subjectAntibióticosspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordUrinary tract infectionsspa
dc.subject.keywordCystoscopyspa
dc.subject.keywordAntibiotic prophylaxisspa
dc.subject.keywordMeta-Analysisspa
dc.subject.lembEnfermedades del aparato urinariospa
dc.subject.lembInfeccionesspa
dc.titleEfficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículo de revisión spa
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