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Structural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteins

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dc.creatorCifuentes, Gladysspa
dc.creatorVanegas, Magnoliaspa
dc.creatorMartinez, Nora Lorenaspa
dc.creatorPirajan, Camilospa
dc.creatorPatarroyo, Manuel Elkinspa
dc.date.accessioned2020-05-26T00:02:36Z
dc.date.available2020-05-26T00:02:36Z
dc.date.created2009spa
dc.description.abstractA fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by blocking the parasite's access to hepatic cells, and/or proteins involved in the development of this stage, amongst which are included the Liver Stage Antigen-1 (LSA-1) and the Sporozoite and Liver Stage Antigen (SALSA). Our studies have focused on the search for an association between the structure of high activity binding peptides (HABPs), including both conserved native and their modified analogues, and their ability to bind to the MHC Class II HLA-DR molecules during formation of the MHCII-peptide-TCR complex leading to inducing the appropriate immune response. These studies are part of a logical and rational strategy for developing multi-stage, multi-component, minimal subunit-based vaccines, mainly against the P. falciparum malaria. © 2009 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2009.04.138
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23506
dc.language.isoengspa
dc.relation.citationEndPage460
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage455
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 384
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.384, No.4 (2009); pp. 455-460spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-65649150730&doi=10.1016%2fj.bbrc.2009.04.138&partnerID=40&md5=f675281f5f8f822763200d20c175c9ffspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHLA DR antigenspa
dc.subject.keywordSubuniteng
dc.subject.keywordMajor histocompatibility antigen class 2spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordParasite antigenspa
dc.subject.keywordPlasmodium falciparum malarial proteinspa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordSporozoite and liver stage antigenspa
dc.subject.keywordT lymphocyte receptorspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAnimal cellspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordAntigen structurespa
dc.subject.keywordArticlespa
dc.subject.keywordCell invasionspa
dc.subject.keywordControlled studyspa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordLiver cellspa
dc.subject.keywordMalariaspa
dc.subject.keywordMonkeyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSporozoitespa
dc.subject.keywordAmino Acid Sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordHLA-DR Antigensspa
dc.subject.keywordImmunizationspa
dc.subject.keywordLiverspa
dc.subject.keywordMalaria Vaccinesspa
dc.subject.keywordMolecular Sequence Dataspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtein Structureeng
dc.subject.keywordProtozoan Proteinsspa
dc.subject.keywordVaccineseng
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordHLA-dr?1* moleculesspa
dc.subject.keywordLSA-1spa
dc.subject.keywordMalariaspa
dc.subject.keywordMHCII-peptide-TCR complexspa
dc.subject.keywordSALSAspa
dc.titleStructural characteristics of immunogenic liver-stage antigens derived from P. falciparum malarial proteinsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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