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A highly infective plasmodium vivax strain adapted to Aotus monkeys: quantitative haematological and molecular determinations useful for P. vivax malaria vaccine development

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dc.creatorPicode Coaña, Yagospa
dc.creatorRodriguez, Josefaspa
dc.creatorGuerrero, Eduarspa
dc.creatorBarrero, Carlosspa
dc.creatorRodríguez, Raúlspa
dc.creatorMendoza, Marcelaspa
dc.creatorPatarroyo, Manuel A.
dc.date.accessioned2020-08-19T14:42:27Z
dc.date.available2020-08-19T14:42:27Z
dc.date.created2003-09-08spa
dc.description.abstractThe New World primate Aotus nancymaae is susceptible to infection by the human malaria parasite Plasmodium vivax and has therefore been recommended by the World Health Organization as a model for malaria vaccine candidate evaluation. We report the isolation, adaptation, titration and genetic characterization of a P. vivax wild strain in splenectomized A. nancymaae monkeys. Parasitemia remained high after 22 passages, reaching 7.88% by Giemsa and Acridine Orange staining and Real-Time PCR determination, making this P. vivax strain a highly infective and reliable asset to be used in P. vivax biological studies and vaccine development.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/S0264-410X(03)00278-0
dc.identifier.issnISSN: 0264-410X
dc.identifier.issnEISSN: 1873-2518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27498
dc.language.isoengspa
dc.publisherThe Japanese Society for Vaccinologyspa
dc.publisherElsevierspa
dc.relation.citationEndPage3937
dc.relation.citationIssueNo. 25-26
dc.relation.citationStartPage3930
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 21
dc.relation.ispartofVaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.21, No.25-26 (2003); pp. 3930-3937 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X03002780?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceVaccinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAotusspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordMalariaspa
dc.titleA highly infective plasmodium vivax strain adapted to Aotus monkeys: quantitative haematological and molecular determinations useful for P. vivax malaria vaccine developmentspa
dc.title.TranslatedTitleUna cepa de Plasmodium vivax altamente infecciosa adaptada a los monos Aotus: determinaciones hematológicas y moleculares cuantitativas útiles para el desarrollo de una vacuna contra el paludismo por P. vivaxspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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