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RNA-seq in kinetoplastids: A powerful tool for the understanding of the biology and host-pathogen interactions

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dc.creatorPatino L.H.spa
dc.creatorRamírez, Juan Davidspa
dc.date.accessioned2020-05-26T00:11:27Z
dc.date.available2020-05-26T00:11:27Z
dc.date.created2017spa
dc.description.abstractThe kinetoplastids include a large number of parasites responsible for serious diseases in humans and animals (Leishmania and Trypanosoma brucei) considered endemic in several regions of the world. These parasites are characterized by digenetic life cycles that undergo morphological and genetic changes that allow them to adapt to different microenvironments on their vertebrates and invertebrates hosts. Recent advances in ´omics´ technology, specifically transcriptomics have allowed to reveal aspects associated with such molecular changes. So far, different techniques have been used to evaluate the gene expression profile during the various stages of the life cycle of these parasites and during the host-parasite interactions. However, some of them have serious drawbacks that limit the precise study and full understanding of their transcriptomes. Therefore, recently has been implemented the latest technology (RNA-seq), which overcomes the drawbacks of traditional methods. In this review, studies that so far have used RNA-seq are presented and allowed to expand our knowledge regarding the biology of these parasites and their interactions with their hosts. © 2017 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2017.02.003
dc.identifier.issn15671348
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24303
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage282
dc.relation.citationStartPage273
dc.relation.citationTitleInfection, Genetics and Evolution
dc.relation.citationVolumeVol. 49
dc.relation.ispartofInfection, Genetics and Evolution, ISSN:15671348, Vol.49,(2017); pp. 273-282spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85012180606&doi=10.1016%2fj.meegid.2017.02.003&partnerID=40&md5=d9a7983c59fca2291dec08b32d82f715spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMessenger RNAspa
dc.subject.keywordProtozoaneng
dc.subject.keywordRibosome RNAspa
dc.subject.keyworddevelopment and agingeng
dc.subject.keywordTranscriptomespa
dc.subject.keywordProtozoal RNAspa
dc.subject.keywordTranscriptomespa
dc.subject.keyword3' untranslated regionspa
dc.subject.keyword5' untranslated regionspa
dc.subject.keywordAfrican trypanosomiasisspa
dc.subject.keywordDNA replicationspa
dc.subject.keywordGene duplicationspa
dc.subject.keywordGene expression profilingspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordIn vitro studyspa
dc.subject.keywordLeishmania amazonensisspa
dc.subject.keywordLeishmania donovanispa
dc.subject.keywordLeishmania majorspa
dc.subject.keywordLeishmania mexicanaspa
dc.subject.keywordLife cycle stagespa
dc.subject.keywordMeasurement precisionspa
dc.subject.keywordMicroarray analysisspa
dc.subject.keywordMucocutaneous leishmaniasisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPolyadenylationspa
dc.subject.keywordReviewspa
dc.subject.keywordRNA sequencespa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSkin leishmaniasisspa
dc.subject.keywordTranscriptomicsspa
dc.subject.keywordTrypanosoma brucei gambiensespa
dc.subject.keywordAnimalspa
dc.subject.keywordDipteraspa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGrowtheng
dc.subject.keywordHigh throughput sequencingspa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordInsect vectorspa
dc.subject.keywordLeishmaniaspa
dc.subject.keywordMacrophagespa
dc.subject.keywordParasitologyspa
dc.subject.keywordTrypanosoma brucei bruceispa
dc.subject.keywordAnimalsspa
dc.subject.keywordDipteraspa
dc.subject.keywordGene Expression Profilingspa
dc.subject.keywordGene Expression Regulationspa
dc.subject.keywordHigh-Throughput Nucleotide Sequencingspa
dc.subject.keywordHost-Parasite Interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordInsect Vectorsspa
dc.subject.keywordLeishmaniaspa
dc.subject.keywordLife Cycle Stagesspa
dc.subject.keywordMacrophagesspa
dc.subject.keywordMicroarray Analysisspa
dc.subject.keywordRNAeng
dc.subject.keywordTranscriptomespa
dc.subject.keywordTrypanosoma brucei bruceispa
dc.subject.keywordMicroarraysspa
dc.subject.keywordRNA-seqspa
dc.subject.keywordTranscriptomespa
dc.subject.keywordTranscriptomicsspa
dc.titleRNA-seq in kinetoplastids: A powerful tool for the understanding of the biology and host-pathogen interactionsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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