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Myalgic encephalomyelitis/chronic fatigue syndrome: A comprehensive review

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dc.creatorCortes Rivera, Mateospa
dc.creatorMastronardi, Claudiospa
dc.creatorSilva-Aldana, Claudia Tspa
dc.creatorArcos-Burgos, Mauriciospa
dc.creatorLidbury, Brett Aspa
dc.date.accessioned2020-05-26T00:06:02Z
dc.date.available2020-05-26T00:06:02Z
dc.date.created2019spa
dc.description.abstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology that is recognized by the World Health Organization (WHO) and the United States Center for Disease Control and Prevention (US CDC) as a disorder of the brain. The disease predominantly affects adults, with a peak age of onset of between 20 and 45 years with a female to male ratio of 3:1. Although the clinical features of the disease have been well established within diagnostic criteria, the diagnosis of ME/CFS is still of exclusion, meaning that other medical conditions must be ruled out. The pathophysiological mechanisms are unclear but the neuro-immuno-endocrinological pattern of CFS patients gleaned from various studies indicates that these three pillars may be the key point to understand the complexity of the disease. At the moment, there are no specific pharmacological therapies to treat the disease, but several studies’ aims and therapeutic approaches have been described in order to benefit patients’ prognosis, symptomatology relief, and the recovery of pre-existing function. This review presents a pathophysiological approach to understanding the essential concepts of ME/CFS, with an emphasis on the population, clinical, and genetic concepts associated with ME/CFS. © 2019 by the authors.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/diagnostics9030091
dc.identifier.issn20754418
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23851
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 3
dc.relation.citationTitleDiagnostics
dc.relation.citationVolumeVol. 9
dc.relation.ispartofDiagnostics, ISSN:20754418, Vol.9, No.3 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85072609855&doi=10.3390%2fdiagnostics9030091&partnerID=40&md5=aea6548dca69964dcf1674cd9d08fabbspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keyword2',5' oligoadenylate synthetasespa
dc.subject.keywordHydrocortisonespa
dc.subject.keywordImmunoglobulinspa
dc.subject.keywordNeurotransmitterspa
dc.subject.keywordRibonuclease lspa
dc.subject.keywordSerotoninspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordB lymphocyte subpopulationspa
dc.subject.keywordCell activationspa
dc.subject.keywordCentral nervous system diseasespa
dc.subject.keywordChronic fatigue syndromespa
dc.subject.keywordClinical featurespa
dc.subject.keywordDna modificationspa
dc.subject.keywordEpigeneticsspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGlia cellspa
dc.subject.keywordHumanspa
dc.subject.keywordHydrocortisone blood levelspa
dc.subject.keywordHypothalamus hypophysis adrenal systemspa
dc.subject.keywordImmune dysregulationspa
dc.subject.keywordImmune systemspa
dc.subject.keywordImmunoglobulin blood levelspa
dc.subject.keywordInflammationspa
dc.subject.keywordNatural killer cellspa
dc.subject.keywordNervous system inflammationspa
dc.subject.keywordNeuroendocrinologyspa
dc.subject.keywordNeuroimmunologyspa
dc.subject.keywordOxidative stressspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPrognosisspa
dc.subject.keywordReviewspa
dc.subject.keywordSensitizationspa
dc.subject.keywordSerotoninergic transmissionspa
dc.subject.keywordBiomarkerspa
dc.subject.keywordChronic fatigue syndromespa
dc.subject.keywordEpstein barr virusspa
dc.subject.keywordHypothalamic–pituitary–adrenal axisspa
dc.subject.keywordImmunologicalspa
dc.subject.keywordMyalgic encephalomyelitisspa
dc.subject.keywordNeuroimmunespa
dc.titleMyalgic encephalomyelitis/chronic fatigue syndrome: A comprehensive reviewspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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