Ítem
Solo Metadatos

IgE responses to Ascaris and mite tropomyosins are risk factors for asthma

Mostrar el registro sencillo de la publicación
dc.creatorAhumada, V.spa
dc.creatorGarcía, E.spa
dc.creatorDennis Verano, Rodolfo Joséspa
dc.creatorRojas, M. X.spa
dc.creatorRondón, M. A.spa
dc.creatorPérez, A.spa
dc.creatorPeñaranda, A.spa
dc.creatorBarragán González, Ana Maríaspa
dc.creatorJimenez, S.spa
dc.creatorKennedy, M. W.spa
dc.creatorCaraballo, L.spa
dc.date.accessioned2020-05-26T00:04:12Z
dc.date.available2020-05-26T00:04:12Z
dc.date.created2015spa
dc.description.abstractBackground: The relationship between helminthiases and allergy is a matter of considerable interest and research. In the tropics, house dust mite exposure, a known risk factor for asthma, is frequently concurrent with helminth infections. It remains to be defined whether infection with the common roundworm Ascaris or its bystander immunological effects influence the prevalence and pathogenesis of asthma independently of mite sensitization. Objective: To investigate the relationship between the IgE responses to Ascaris and its purified allergens and the risk of asthma in a tropical country. Methods: A nested case-control study was performed in 356 subjects who reported current and past asthma symptoms (asthmatics) and 435 controls that had never experienced such symptoms. They were tested for serum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin) and GST (glutathione transferase). In addition, specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis and their tropomyosins Der p 10 and Blo t 10 was measured. Sensitization was defined as a positive specific IgE result to any extract or recombinant allergen. Results: Sensitization to Ascaris and D. pteronyssinus was independently associated with asthma after adjustment for age, gender, socio-economic stratum, city and other IgE levels (adjusted ORs: 2.17; 95% CI 1.37-3.42 and 2.46; 95% CI 1.54-3.92), respectively. There was also a significant association with sensitization to the highly allergenic and cross-reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (aORs: 1.76; 95% CI 1.21-2.57, 1.64; 95% CI 1.14-2.35 and 1.51; 95% CI 1.02-2.24), respectively. Conclusion and Clinical Relevance: IgE responses to Ascaris are associated with asthma symptoms in a population living in the tropics. Sensitization to the cross-reactive Ascaris and mite tropomyosins partially underlies this finding. These results have potential relevance in asthma diagnosis and management. © 2015 John Wiley and Sons Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/cea.12513
dc.identifier.issn09547894
dc.identifier.issn13652222
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23666
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage1200
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1189
dc.relation.citationTitleClinical and Experimental Allergy
dc.relation.citationVolumeVol. 45
dc.relation.ispartofClinical and Experimental Allergy, ISSN:09547894, 13652222, Vol.45, No.7 (2015); pp. 1189-1200spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84930889468&doi=10.1111%2fcea.12513&partnerID=40&md5=cfcaaf23b7329ac61c42b3eedb9cde35spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulin Espa
dc.subject.keywordRecombinant allergenspa
dc.subject.keywordTropomyosinspa
dc.subject.keywordAllergenspa
dc.subject.keywordImmunoglobulin Espa
dc.subject.keywordTropomyosinspa
dc.subject.keywordAdultspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordArticlespa
dc.subject.keywordAscarisspa
dc.subject.keywordAsthmaspa
dc.subject.keywordBlomia tropicalisspa
dc.subject.keywordCase control studyspa
dc.subject.keywordClinical researchspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCross reactionspa
dc.subject.keywordDermatophagoidesspa
dc.subject.keywordDermatophagoides pteronyssinusspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordHelminthiasisspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunomodulationspa
dc.subject.keywordMalespa
dc.subject.keywordMolecular diagnosisspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordPurificationspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSensitizationspa
dc.subject.keywordTropicsspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAgespa
dc.subject.keywordAnimalspa
dc.subject.keywordAntibody specificityspa
dc.subject.keywordAsthmaspa
dc.subject.keywordBloodspa
dc.subject.keywordChildspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMitespa
dc.subject.keywordOdds ratiospa
dc.subject.keywordRisk factorspa
dc.subject.keywordSex differencespa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAge Factorsspa
dc.subject.keywordAllergensspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntibody Specificityspa
dc.subject.keywordAscarisspa
dc.subject.keywordAsthmaspa
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordChildspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordImmunoglobulin Espa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordMitesspa
dc.subject.keywordOdds Ratiospa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordSex Factorsspa
dc.subject.keywordTropomyosinspa
dc.subject.keywordYoung Adultspa
dc.subject.keywordAscarisspa
dc.subject.keywordAllergenspa
dc.subject.keywordAscariasisspa
dc.subject.keywordAsthmaspa
dc.subject.keywordIgespa
dc.subject.keywordMitespa
dc.subject.keywordRecombinant allergensspa
dc.subject.keywordTropomyosinspa
dc.titleIgE responses to Ascaris and mite tropomyosins are risk factors for asthmaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos