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Detection of mammagloblin by RT-PCR as a biomarker for lymph node metastasis in breast cancer patients: A systematic review and meta-analysis

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dc.creatorMonsalve-Lancheros, Anaspa
dc.creatorIbáñez Pinilla, Milcíadesspa
dc.creatorRamírez Clavijo, Sandra Rocío
dc.date.accessioned2020-05-25T23:58:17Z
dc.date.available2020-05-25T23:58:17Z
dc.date.created2019spa
dc.description.abstractBackground This meta-analysis presents evidence regarding the diagnostic accuracy of mammaglobin detected using the RT-PCR technique, related to the presence of sentinel node metastasis in breast cancer patients. Methods The following databases were consulted: Cochrane, Lilacs, Scielo, Hinary, PubMed, Elsevier, Embase, ProQuest, the Universidad del Rosario´s Centro de Recursos Para el Apren-dizaje y la Investigación (CRAI-UR) [Resource Center for Learning and Research], and the Google Scholar search engine. The quality of the studies was assessed using the QUADAS-2 and CASpe tools. The selected studies presented the necessary data to calculate diagnostic validity index of mammaglobin detection using RT-PCR, compared with the reference standard test. Global values for the sensitivity, specificity, positive predictive value, negative predictive value, probability ratios, diagnostic ORs, and summary ROC curves of this meta-analysis were obtained using the Meta-DiSc 1.4 program. Results Initially, 731 articles were obtained; but only 25 were included in the meta-analysis. Sensitivity was 84% (95% CI: 83% - 86%), and specificity was 92% (95% CI: 91% - 93%). Positive and negative predictive values were 9.26 (95% CI: 6.47–13.26) and 0.17 (95% CI: 0.13–0.23), respectively. The diagnostic OR was 66.34 (95% CI: 42.52–103.52). The predictive area under the sROC curve was 94.78 (Q = 0.8876). Conclusions The evaluated diagnostic index showed that the expression of the mammaglobin biomarker has diagnostic prediction for detecting lymph node metastasis in breast cancer patients, when analyzed using RT-PCR, although more than 50% heterogeneity was found. © 2019 Monsalve-Lancheros et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0216989
dc.identifier.issn19326203
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22834
dc.language.isoengspa
dc.publisherPublic Library of Sciencespa
dc.relation.citationIssueNo. 5
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 14
dc.relation.ispartofPLoS ONE, ISSN:19326203, Vol.14, No.5 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85066255280&doi=10.1371%2fjournal.pone.0216989&partnerID=40&md5=6f47681e17c66fab94540984b0298fe9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBiological markerspa
dc.subject.keywordMammagloblin proteinspa
dc.subject.keywordTumoreng
dc.subject.keywordNeoplasticeng
dc.subject.keywordSecretory proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordMammaglobin aspa
dc.subject.keywordTumor markerspa
dc.subject.keywordArticlespa
dc.subject.keywordBreast cancerspa
dc.subject.keywordCancer diagnosisspa
dc.subject.keywordCancer patientspa
dc.subject.keywordDiagnostic accuracyspa
dc.subject.keywordDiagnostic test accuracy studyspa
dc.subject.keywordDiagnostic valuespa
dc.subject.keywordHumanspa
dc.subject.keywordLymph node metastasisspa
dc.subject.keywordPredictive valuespa
dc.subject.keywordReverse transcription polymerase chain reactionspa
dc.subject.keywordSensitivity and specificityspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordBreast tumorspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordFemalespa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordMeta analysisspa
dc.subject.keywordMetabolismspa
dc.subject.keywordObservational studyspa
dc.subject.keywordPathologyspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPrognosisspa
dc.subject.keywordReceiver operating characteristicspa
dc.subject.keywordReproducibilityspa
dc.subject.keywordBiomarkerseng
dc.subject.keywordBreast neoplasmsspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordFemalespa
dc.subject.keywordGene expression regulationeng
dc.subject.keywordHumansspa
dc.subject.keywordLymphatic metastasisspa
dc.subject.keywordMammaglobin aspa
dc.subject.keywordObservational studies as topicspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPredictive value of testsspa
dc.subject.keywordPrognosisspa
dc.subject.keywordReproducibility of resultsspa
dc.subject.keywordRoc curvespa
dc.subject.keywordSensitivity and specificityspa
dc.titleDetection of mammagloblin by RT-PCR as a biomarker for lymph node metastasis in breast cancer patients: A systematic review and meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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