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PvGAMA reticulocyte binding activity: predicting conserved functional regions by natural selection analysis

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dc.creatorBaquero, Luis A.
dc.creatorMoreno-Perez, Darwin Andres
dc.creatorGarzón-Ospina, Diego
dc.creatorForero Rodríguez, Johanna
dc.creatorOrtiz-Suárez, Heidy D.
dc.creatorPatarroyo, Manuel A.
dc.creator.googleBaquero, Luis Albertospa
dc.creator.googleMoreno-Pérez, Darwin A.spa
dc.creator.googleGarzón-Ospina, Diegospa
dc.creator.googleForero-Rodríguez, Johannaspa
dc.creator.googleOrtiz-Suárez, Heidy D.spa
dc.creator.googlePatarroyo, Manuel A.spa
dc.date.accessioned2020-04-01T22:28:57Z
dc.date.available2020-04-01T22:28:57Z
dc.date.created2017
dc.date.issued2017
dc.description.abstractBackground: Adhesin proteins are used by Plasmodium parasites to bind and invade target cells. Hence, characterising molecules that participate in reticulocyte interaction is key to understanding the molecular basis of Plasmodium vivax invasion. This study focused on predicting functionally restricted regions of the P. vivax GPI-anchored micronemal antigen (PvGAMA) and characterising their reticulocyte binding activity. Results: The pvgama gene was initially found in P. vivax VCG-I strain schizonts. According to the genetic diversity analysis, PvGAMA displayed a size polymorphism very common for antigenic P. vivax proteins. Two regions along the antigen sequence were highly conserved among species, having a negative natural selection signal. Interestingly, these regions revealed a functional role regarding preferential target cell adhesion. Conclusions: To our knowledge, this study describes PvGAMA reticulocyte binding properties for the first time. Conserved functional regions were predicted according to natural selection analysis and their binding ability was confirmed. These findings support the notion that PvGAMA may have an important role in P. vivax merozoite adhesion to its target cells. © 2017 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s13071-017-2183-8
dc.identifier.issn1756-3305
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21384
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleParasites and Vectors
dc.relation.citationVolumeVol. 10
dc.relation.ispartofParasites and Vectors, ISSN: 1756-3305 Vol. 10, No. 1 (2017)spa
dc.relation.urihttps://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/s13071-017-2183-8spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectProteína adhesivaspa
dc.subjectPlasmodium vivaxspa
dc.subjectDiversidad genéticaspa
dc.subjectRegión funcional conservadaspa
dc.subjectActividad de unión a reticulocitosspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordAdhesin proteinspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordGenetic diversityspa
dc.subject.keywordConserved functional regionspa
dc.subject.keywordReticulocyte binding activityspa
dc.subject.lembPlasmodium vivaxspa
dc.subject.lembReticulositosspa
dc.subject.lembMalariaspa
dc.titlePvGAMA reticulocyte binding activity: predicting conserved functional regions by natural selection analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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