Lupus nephritis: an overview of recent findings

Herrera-Díaz, Ana-Catalina; Zubiria Salgado, Alberto de

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Lupus nephritis: an overview of recent findings

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dc.audience	Comunidad Rosarista	spa
dc.creator	Herrera-Díaz, Ana-Catalina
dc.creator	Zubiria Salgado, Alberto de
dc.creator.google	Herrera-Díaz, Ana-Catalina
dc.creator.google	Zubiria Salgado, Alberto de
dc.date.accessioned	2014-08-12T20:05:40Z
dc.date.available	2014-08-12T20:05:40Z
dc.date.created	2012
dc.date.issued	2012
dc.description.abstract	Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response. IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation. This leads to monocytes and polymorphonuclear cells chemotaxis. Subsequent release of proteases generates endothelial injury and mesangial proliferation. Presence of ICs promotes adaptive immune response and causes dendritic cells to release type I interferon. This induces maturation and activation of infiltrating T cells, and amplification of Th2, Th1 and Th17 lymphocytes. Each of them, amplify B cells and activates macrophages to release more proinflammatory molecules, generating effector cells that cannot be modulated promoting kidney epithelial proliferation and fibrosis. Herein immunopathological findings of LN are reviewed.	eng
dc.format.medium	Recurso electrónico	spa
dc.format.mimetype	application/pdf
dc.format.tipo	Documento	spa
dc.identifier.issn	ISSN:2090-0430
dc.identifier.uri	http://repository.urosario.edu.co/handle/10336/8821
dc.language.iso	eng
dc.publisher	Universidad del Rosario	spa
dc.relation.citationTitle	Autoimmune Diseases
dc.relation.ispartof	Autoimmune Diseases, ISSN 2090-04-30, 2012	spa
dc.rights.accesRights	info:eu-repo/semantics/openAccess
dc.rights.acceso	Abierto (Texto completo)	spa
dc.rights.licencia	EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.	spa
dc.source.instname	instname:Universidad del Rosario	spa
dc.source.reponame	reponame:Repositorio Institucional EdocUR	spa
dc.subject.ddc	Enfermedades
dc.subject.decs	Nefritis lúpica	spa
dc.subject.decs	Enfermedades de los riñones	spa
dc.subject.decs	Células dendríticas	spa
dc.subject.decs	Fibrosis	spa
dc.subject.decs	Lupus eritematoso sistémico	spa
dc.title	Lupus nephritis: an overview of recent findings	spa
dc.type	article	eng
dc.type.hasVersion	info:eu-repo/semantics/acceptedVersion
dc.type.spa	Artículo	spa