Ítem
Acceso Abierto

STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

Mostrar el registro sencillo de la publicación
dc.creatorPalomino-Morales, R Jspa
dc.creatorRojas-Villarraga, Aspa
dc.creatorGonzález, C Ispa
dc.creatorRamírez, Gspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorMartín, Jspa
dc.date.accessioned2020-05-26T00:09:10Z
dc.date.available2020-05-26T00:09:10Z
dc.date.created2008spa
dc.description.abstractThe aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/gene.2008.30
dc.identifier.issn14664879
dc.identifier.issn14765470
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24142
dc.language.isoengspa
dc.relation.citationEndPage382
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage379
dc.relation.citationTitleGenes and Immunity
dc.relation.citationVolumeVol. 9
dc.relation.ispartofGenes and Immunity, ISSN:14664879, 14765470, Vol.9, No.4 (2008); pp. 379-382spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-44849140782&doi=10.1038%2fgene.2008.30&partnerID=40&md5=653c2cbcb21cbd32c5d5b47282c17e0bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordComplement component C5spa
dc.subject.keywordRheumatoideng
dc.subject.keywordSTAT4 proteinspa
dc.subject.keywordSingle Nucleotideeng
dc.subject.keywordSystemiceng
dc.subject.keywordTumor necrosis factor receptor associated factor 1spa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCase control studyspa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMouse strainspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein variantspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAllelesspa
dc.subject.keywordArthritiseng
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordCohort Studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordPolymorphismeng
dc.subject.keywordRisk Factorsspa
dc.subject.keywordSTAT4 Transcription Factorspa
dc.subject.keywordTNF Receptor-Associated Factor 1spa
dc.subject.keywordVariation (Genetics)spa
dc.titleSTAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombiansspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
gene200830.pdf
Tamaño:
117.95 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos