Ítem
Solo Metadatos

Influence of STAT4 polymorphism in primary Sjögren's syndrome

Mostrar el registro sencillo de la publicación
dc.creatorPalomino-Morales R.J.spa
dc.creatorDiaz-Gallo L.-M.spa
dc.creatorWitte T.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorMartín J.spa
dc.date.accessioned2020-05-25T23:56:31Z
dc.date.available2020-05-25T23:56:31Z
dc.date.created2010spa
dc.description.abstractObjective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 = 10-6, OR 1.40, 95% CI 1.21-1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene. The Journal of Rheumatology Copyright © 2010. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3899/jrheum.091007
dc.identifier.issn14992752
dc.identifier.issn0315162X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22451
dc.language.isoengspa
dc.relation.citationEndPage1019
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage1016
dc.relation.citationTitleJournal of Rheumatology
dc.relation.citationVolumeVol. 37
dc.relation.ispartofJournal of Rheumatology, ISSN:14992752, 0315162X, Vol.37, No.5 (2010); pp. 1016-1019spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77951826130&doi=10.3899%2fjrheum.091007&partnerID=40&md5=0e9c690b5b38028dc9542eef6e016a46spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordSTAT4 proteinspa
dc.subject.keywordSingle Nucleotideeng
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCohort analysisspa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordDNA polymorphismspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordGermanyspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordAdultspa
dc.subject.keywordAllelesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenetic Association Studiesspa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordOdds Ratiospa
dc.subject.keywordPhenotypespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordSTAT4 Transcription Factorspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGenetic studiesspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordSTAT4spa
dc.titleInfluence of STAT4 polymorphism in primary Sjögren's syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos