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Genomics of novel influenza A virus (H18N12) in bats, Caribe Colombia

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dc.creatorMattar,Salimspa
dc.creatorRamírez González, Juan Davidspa
dc.creatorArrieta, Germánspa
dc.creatorHoyos, Richardspa
dc.creatorGaray, Evelinspa
dc.creatorAlemán-Santos, Mairaspa
dc.creatorBertel, Valeriaspa
dc.creatorLópez, Yesicaspa
dc.creatorRivero, Ricardospa
dc.creatorGastelbondo-Pastrana, Berthaspa
dc.creatorMartínez-Bravo, Catyspa
dc.creatorEcheverri-De la Hoz, Danielspa
dc.date.accessioned2025-07-21T16:44:16Z
dc.date.available2025-07-21T16:44:16Z
dc.date.created2025-12-01spa
dc.date.issued2025-12-01spa
dc.description.abstractInfluenza viruses are highly capable of mutating and adapting in mammalian hosts. While these viruses have been extensively studied in birds, research on their presence in bats has been limited. However, influenza viruses circulating in bats have shown notable molecular divergence. The present study aimed to characterize the phylogenetic, evolutionary, and antigenic relationships of an influenza A virus detected in the fishing bat Noctilio albiventris. As part of a pathogen surveillance study of public health interest, 159 rectal samples were collected from bats in the Colombian Caribbean. The samples were sequenced using RNA-Seq.A genome (eight viral contigs) associated with the Orthomyxoviridae family was identified in a pool. Most segments showed approximately 90% similarity with H18N11, except for the neuraminidase. Analysis of the N protein shows that occupies a basal position relative to the N11 subtype, with its divergence date estimated to be approximately 50 years earlier than the earliest reported N11 sequence. 3D modeling identified three mutations (K363R, T242K, and I139V), which may enhance interaction with the HLA-DR of bats. The analyses and antigenic divergence observed in the N protein of N. albiventris suggests the existence of a new subtype (H18N12) with unknown pathogenicity, which requires further investigation.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41598-025-91026-8spa
dc.identifier.issn2045-2322spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46074
dc.language.isoengspa
dc.publisherNaturespa
dc.relation.ispartofScientific Reports volume 15, Article number: 6507 (2025)spa
dc.relation.urihttps://www.nature.com/articles/s41598-025-91026-8spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceScientific Reportsspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordNeuraminidaseeng
dc.subject.keywordNoctilio albiventriseng
dc.subject.keywordNeotropical batseng
dc.subject.keywordAdaptabilityeng
dc.subject.keywordOrtomyxoviridaeeng
dc.titleGenomics of novel influenza A virus (H18N12) in bats, Caribe Colombiaspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de Investigaciónspa
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