Ítem
Solo Metadatos

Neuroprotective effects of gacyclidine after experimental photochemical spinal cord lesion in adult rats: Dose-window and time-window effects

Mostrar el registro sencillo de la publicación
dc.creatorGaviria M.spa
dc.creatorPrivat A.spa
dc.creatorD'Arbigny P.spa
dc.creatorKamenka J.-M.spa
dc.creatorHaton H.spa
dc.creatorOhanna F.spa
dc.date.accessioned2020-05-25T23:56:22Z
dc.date.available2020-05-25T23:56:22Z
dc.date.created2000spa
dc.description.abstractThe aim of this study was to evaluate the efficacy, optimal dose, and optimal time-window of gacyclidine, a novel N-methyl-D-aspartate (NMDA) receptor antagonist, in terms of its functional, histopathological, and electrophysiological effects after experimental spinal cord injury. The spinal cord of rats was damaged by a photochemical method and the animals were treated by saline or gacyclidine at doses of 1, 2.5, or 5 mg/kg 10 min after injury or gacyclidine 1 mg/kg 10, 30, 60, and 120 min after injury. The time-course of the motor score (walking and inclined-plane stability) was evaluated until day 18, and somatosensory evoked potentials were determined on day 18. The animals were then sacrificed, and the cross-sectional area of the spinal cord (at the epicenter of the injury, above and below the injury) was measured. Walking recovery was better in most of the groups treated after injury than in the untreated injured animals. Motor performances were related to preservation of a larger undamaged area of spinal cord at the level of the injury and, interestingly, with prevention of extension of the anatomical lesion above the level of the injury. Somatosensory evoked potential amplitudes were often higher in treated groups. These results confirm that gacyclidine induces dose-dependent and time-dependent attenuation of spinal cord damage after an experimental vascular lesion. Although all three doses induced neuroprotective effects, recovery was greater and very homogeneous in the group treated with 1 mg/kg. Moreover, recovery was slightly better and more homogeneous within the groups treated 10 and 30 min after injury compared to the other groups. It appears that, according to the existing evidence, NMDA antagonists are an essential component in the elaboration of a neuroprotective strategy after spinal cord trauma.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1089/neu.2000.17.19
dc.identifier.issn8977151
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22409
dc.language.isoengspa
dc.publisherMary Ann Liebert Inc.spa
dc.relation.citationEndPage30
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage19
dc.relation.citationTitleJournal of Neurotrauma
dc.relation.citationVolumeVol. 17
dc.relation.ispartofJournal of Neurotrauma, ISSN:8977151, Vol.17, No.1 (2000); pp. 19-30spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0033973993&doi=10.1089%2fneu.2000.17.19&partnerID=40&md5=c614f5a1f17680852997dea2f03da2b7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGacyclidinespa
dc.subject.keywordN methyl dextro aspartic acid receptor blocking agentspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDose responsespa
dc.subject.keywordEvoked somatosensory responsespa
dc.subject.keywordLocomotionspa
dc.subject.keywordMalespa
dc.subject.keywordMotor performancespa
dc.subject.keywordNeuroprotectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordRatspa
dc.subject.keywordSpinal cord injuryspa
dc.subject.keywordSpinal cord lesionspa
dc.subject.keywordDose-windowspa
dc.subject.keywordGacyclidinespa
dc.subject.keywordN-methyl-d-aspartatespa
dc.subject.keywordPhotochemical lesionspa
dc.subject.keywordSecondary injuryspa
dc.subject.keywordSpinal cord injuryspa
dc.subject.keywordTime-windowspa
dc.titleNeuroprotective effects of gacyclidine after experimental photochemical spinal cord lesion in adult rats: Dose-window and time-window effectsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos