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The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome

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dc.creatorZhao, Binspa
dc.creatorVelasco, Kellyspa
dc.creatorSompallae, Ramakrishnaspa
dc.creatorPfirrmann, Thorstenspa
dc.creatorMasucci, Maria G.spa
dc.creatorLindsten, Kristinaspa
dc.date.accessioned2020-05-26T00:02:39Z
dc.date.available2020-05-26T00:02:39Z
dc.date.created2012spa
dc.description.abstractThe proteasome is the major non-lysosomal proteolytic machine in cells that, through degradation of ubiquitylated substrates, regulates virtually all cellular functions. Numerous accessory proteins influence the activity of the proteasome by recruiting or deubiquitylating proteasomal substrates, or by maintaining the integrity of the complex. Here we show that the ubiquitin specific protease (USP)-4, a deubiquitylating enzyme with specificity for both Lys48 and Lys63 ubiquitin chains, interacts with the S9/Rpn6 subunit of the proteasome via an internal ubiquitin-like (UBL) domain. S9/Rpn6 acts as a molecular clamp that holds together the proteasomal core and regulatory sub-complexes. Thus, the interaction with USP4 may regulate the structure and function of the proteasome or the turnover of specific proteasomal substrates. © 2012 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2012.09.075
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23511
dc.language.isoengspa
dc.relation.citationEndPage496
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage490
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 427
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.427, No.3 (2012); pp. 490-496spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84867851404&doi=10.1016%2fj.bbrc.2012.09.075&partnerID=40&md5=f01fde1d563140837bd6495e448e737espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordLysinespa
dc.subject.keywordtertiaryeng
dc.subject.keywordProteinasespa
dc.subject.keywordUbiquitinspa
dc.subject.keywordUbiquitin specific protease 4spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordEmbryospa
dc.subject.keywordEnzyme bindingspa
dc.subject.keywordEnzyme specificityspa
dc.subject.keywordEnzyme structurespa
dc.subject.keywordEnzyme substratespa
dc.subject.keywordEnzyme substrate complexspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordIn vitro studyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein domainspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordProtein subunitspa
dc.subject.keywordUbiquitinationspa
dc.subject.keywordHek293 cellsspa
dc.subject.keywordHela cellsspa
dc.subject.keywordHumansspa
dc.subject.keywordProteasome endopeptidase complexspa
dc.subject.keywordProtein structureeng
dc.subject.keywordUbiquitin thiolesterasespa
dc.subject.keywordProteasomespa
dc.subject.keywordS9/psmd11/rpn6spa
dc.subject.keywordUbiquitin specific protease 4 (usp4)spa
dc.subject.keywordUbiquitin-like domainspa
dc.titleThe ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasomespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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