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Síndrome de Leucoencefalopatía Posterior Reversible (LSPR): serie de casos de dos instituciones colombianas

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dc.contributor.advisorRomero, Camilo
dc.creatorOrtiz Pereira, Monica Juliana
dc.creatorGaviria-Carrillo, Mariana
dc.creatorRamírez-Guerrero, Sofía
dc.creatorRoa, Luis
dc.creatorRodriguez, Jesús
dc.creatorPalacios, Maria Alejandra
dc.creatorRomero, Camilo
dc.creatorMendoza, Isabel
dc.creatorGallo, Lorena
dc.creator.degreeEspecialista en Neurología
dc.creator.degreeLevelMaestría
dc.date.accessioned2025-08-11T19:45:30Z
dc.date.available2025-08-11T19:45:30Z
dc.date.created2025-06-09
dc.descriptionIntroducción: El síndrome de leucoencefalopatía posterior reversible (SLPR) es una entidad neurológica aguda caracterizada por edema vasogénico, típicamente en regiones posteriores del cerebro. Su estudio en poblaciones latinoamericanas es limitado. Objetivo: Caracterizar clínicamente a pacientes adultos con diagnóstico de SLPR en dos instituciones de Bogotá entre 2018 y 2023. Metodología: Estudio descriptivo de serie de casos. Se incluyeron pacientes mayores de 18 años con diagnóstico clínico e imagenológico de SLPR y algún grado de reversibilidad documentado. Resultados: Se incluyeron 60 pacientes, con una mediana de edad de 50 años (DE ±17). Las manifestaciones clínicas más comunes fueron cefalea (66.7%), alteraciones visuales (60%), convulsiones (58.3%) y encefalopatía (55%). En neuroimagen, el patrón más frecuente fue afectación parieto-occipital bilateral. El 33.4% presentó hemorragia intracraneal, 15% infarto cerebral y 11.7% estado epiléptico. El 21.7% tuvo desenlace clínico desfavorable según la escala de Rankin, sin registrarse mortalidad hospitalaria. Conclusión: Esta es la serie de casos con mayor número de pacientes con SLPR reportada en Colombia hasta la fecha. Nuestros hallazgos reflejan un perfil clínico e imagenológico comparable al descrito en cohortes internacionales, como las de Fugate et al. y Otite et al., aunque con una frecuencia mayor de hemorragia intracraneal y sin muertes hospitalarias. Es importante continuar con esta línea de investigación para describir los casos de SLPR en Latinoamérica con el fin de ampliar el conocimiento de este síndrome en nuestra población para así ajustar estrategias diagnósticas y terapéuticas adaptadas al contexto latinoamericano.
dc.description.abstractIntroduction: Posterior reversible encephalopathy syndrome (PRES) is a neurologic condition marked by vasogenic edema, commonly affecting posterior brain regions. Data on its presentation in Latin American populations remain limited. Objective: To describe the clinical, imaging, and outcome characteristics of adults diagnosed with PRES in two tertiary hospitals in Bogotá, Colombia (2018–2023). Methods: Descriptive retrospective case series. Included adults had a clinical and imaging-based diagnosis of PRES with documented partial or full reversibility. Results: Sixty patients were included. Median age was 50 years (SD ±17). Frequent symptoms included headache (66.7%), visual disturbances (60%), seizures (58.3%), and encephalopathy (55%). Imaging most commonly showed bilateral parieto-occipital involvement. Complications included intracranial hemorrhage (33.4%), cerebral infarction (15%), and status epilepticus (11.7%). Poor clinical outcomes (modified Rankin 3–5) occurred in 21.7% of patients. No in-hospital deaths were reported. Conclusion: This is the largest Colombian PRES case series to date. Our findings align with international cohorts such as those by Fugate et al. and Otite et al., though with a higher frequency of intracranial hemorrhage and no hospital mortality. These results highlight the importance of future multicenter prospective studies to tailor diagnostic and treatment strategies to regional patient characteristics.
dc.format.extent47 pp
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dc.identifier.doihttps://doi.org/10.48713/10336_46258
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46258
dc.language.isospa
dc.publisherUniversidad del Rosario
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.publisher.programEspecialización en Neurología
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dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectEncefefalopatia reversible
dc.subjectSíndrome de leucoencefalopatía posterior reversible
dc.subjectComplicaciones
dc.subjectClinica
dc.subjectEntidad neurológica aguda
dc.subjectEdema vasogénico
dc.subject.keywordPRES
dc.subject.keywordClinical
dc.subject.keywordComplications
dc.subject.keywordVasogenic edema
dc.titleSíndrome de Leucoencefalopatía Posterior Reversible (LSPR): serie de casos de dos instituciones colombianas
dc.title.TranslatedTitlePosterior Reversible Encephalopathy Syndrome: Case Series from Two Colombian Institutions
dc.typemasterThesis
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaDescriptivo observacional retrospectivo
local.department.reportEscuela de Medicina y Ciencias de la Salud
local.regionesBogotá
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