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Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

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dc.creatorChudnovskiy, Alekseyspa
dc.creatorMortha, Arthurspa
dc.creatorKana, Veronikaspa
dc.creatorKennard, Andreaspa
dc.creatorRamírez, Juan David
dc.creatorRahman, Adeebspa
dc.creatorRemark, Romainspa
dc.creatorMogno, Ilariaspa
dc.creatorNg, Rubyspa
dc.creatorGnjatic, Sashaspa
dc.creatorAmir, El-ad Davidspa
dc.creatorSolovyov, Alexanderspa
dc.creatorGreenbaum, Benjaminspa
dc.creatorClemente, Josespa
dc.creatorFaith, Jeremiahspa
dc.creatorBelkaid, Yasminespa
dc.creatorGrigg, Michael E.spa
dc.creatorMerad, Miriamspa
dc.date.accessioned2020-06-11T13:21:15Z
dc.date.available2020-06-11T13:21:15Z
dc.date.created2016-10spa
dc.description.abstractWhile conventional pathogenic protists have been extensively studied, there is an underappreciated constitutive protist microbiota that is an integral part of the vertebrate microbiome. The impact of these species on the host and their potential contributions to mucosal immune homeostasis remain poorly studied. Here, we show that the protozoan Tritrichomonas musculis activates the host epithelial inflammasome to induce IL-18 release. Epithelialderived IL-18 promotes dendritic cell-driven Th1 and Th17 immunity and confers dramatic protection from mucosal bacterial infections. Along with its role as a protistic'' antibiotic, colonization with T. musculis exacerbates the development of T-cell-driven colitis and sporadic colorectal tumors. Our findings demonstrate a novel mutualistic host-protozoan interaction that increases mucosal host defenses at the cost of an increased risk of inflammatory disease.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cell.2016.08.076
dc.identifier.issn0092-8674
dc.identifier.issn1097-4172
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24790
dc.language.isoeng
dc.publisherCellspa
dc.relation.citationEndPage456.e14
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage444
dc.relation.citationTitleCell
dc.relation.citationVolumeVol. 167
dc.relation.ispartofCell, ISSN: 0092-8674;1097-4172, Vol.167, No.2 (2016-10); pp. 444-456.e14spa
dc.relation.urihttp://www.cell.com/article/S0092867416311746/pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAnimalsspa
dc.subject.keywordColitisspa
dc.subject.keywordDientamoebaspa
dc.subject.keywordHost-Parasite Interactionsspa
dc.subject.keywordImmunityspa
dc.subject.keywordMucosalspa
dc.subject.keywordInflammasomesspa
dc.subject.keywordInterleukin-18spa
dc.subject.keywordIntestinal Mucosaspa
dc.subject.keywordMicespa
dc.subject.keywordMicespa
dc.subject.keywordInbred C57BLspa
dc.subject.keywordMicrobiotaspa
dc.subject.keywordSalmonella Infectionsspa
dc.subject.keywordSalmonella typhimuriumspa
dc.subject.keywordSymbiosisspa
dc.subject.keywordTh1 Cellsspa
dc.subject.keywordTh17 Cellsspa
dc.subject.keywordTrichomonasspa
dc.subject.keywordTrichomonas Infectionsspa
dc.titleHost-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasomespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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