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New insights in the cytogenetic practice: Karyotypic chaos, non-clonal chromosomal alterations and chromosomal instability in human cancer and therapy response

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dc.creatorRangel, Nelsonspa
dc.creatorForero-Castro, Maribelspa
dc.creatorRondón-Lagos, Milenaspa
dc.date.accessioned2020-05-26T00:09:14Z
dc.date.available2020-05-26T00:09:14Z
dc.date.created2017spa
dc.description.abstractRecently, non-clonal chromosomal alterations previously unappreciated are being proposed to be included in cytogenetic practice. The aim of this inclusion is to obtain a greater understanding of chromosomal instability (CIN) and tumor heterogeneity and their role in cancer evolution and therapy response. Although several genetic assays have allowed the evaluation of the variation in a population of cancer cells, these assays do not provide information at the level of individual cells, therefore limiting the information of the genomic diversity within tumors (heterogeneity). The karyotype is one of the few available cytogenetic techniques that allow us not only to identify the chromosomal alterations present within a single cell, but also allows us to profile both clonal (CCA) and non-clonal chromosomal alterations (NCCAs). A greater understanding of CIN and tumor heterogeneity in cancer could not only improve existing therapeutic regimens but could also be used as targets for the design of new therapeutic approaches. In this review we indicate the importance and significance of karyotypic chaos, NCCAs and CIN in the prognosis of human cancers. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/genes8060155
dc.identifier.issn20734425
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24146
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationEndPage29
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage2
dc.relation.citationTitleGenes
dc.relation.citationVolumeVol. 8
dc.relation.ispartofGenes, ISSN:20734425, Vol.8, No.6 (2017); pp. 2-29spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85020395207&doi=10.3390%2fgenes8060155&partnerID=40&md5=153e171c8c528eb8d4a5d5d6c8701a8espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordArsenic trioxidespa
dc.subject.keywordCetuximabspa
dc.subject.keywordDasatinibspa
dc.subject.keywordDoxorubicinspa
dc.subject.keywordGefitinibspa
dc.subject.keywordImatinibspa
dc.subject.keywordLapatinibspa
dc.subject.keywordLenalidomidespa
dc.subject.keywordMomelotinibspa
dc.subject.keywordNilotinibspa
dc.subject.keywordPanitumumabspa
dc.subject.keywordRapamycinspa
dc.subject.keywordRetinoic acidspa
dc.subject.keywordTamoxifenspa
dc.subject.keywordTrastuzumabspa
dc.subject.keywordAcute lymphoblastic leukemiaspa
dc.subject.keywordAcute myeloid leukemiaspa
dc.subject.keywordBreast cancerspa
dc.subject.keywordCancer cellspa
dc.subject.keywordCancer radiotherapyspa
dc.subject.keywordChromoplexyspa
dc.subject.keywordChromosomal instabilityspa
dc.subject.keywordChromosome aberrationspa
dc.subject.keywordChromosome breakagespa
dc.subject.keywordChromosome damagespa
dc.subject.keywordChromosome fragmentationspa
dc.subject.keywordChromosome rearrangementspa
dc.subject.keywordChromothripsisspa
dc.subject.keywordClonal chromosome alterationspa
dc.subject.keywordCytogeneticsspa
dc.subject.keywordGenetic heterogeneityspa
dc.subject.keywordGenetic variationspa
dc.subject.keywordHumanspa
dc.subject.keywordKaryotypingspa
dc.subject.keywordLymphomaspa
dc.subject.keywordMalignant neoplasmspa
dc.subject.keywordMitosisspa
dc.subject.keywordMyelodysplastic syndromespa
dc.subject.keywordMyeloid leukemiaspa
dc.subject.keywordNeoplasmspa
dc.subject.keywordNon clonal chromosome alterationspa
dc.subject.keywordPromyelocytic leukemiaspa
dc.subject.keywordReviewspa
dc.subject.keywordSolid malignant neoplasmspa
dc.subject.keywordTreatment responsespa
dc.subject.keywordTumor microenvironmentspa
dc.subject.keywordCancerspa
dc.subject.keywordChromosomal instabilityspa
dc.subject.keywordClonal chromosomal alterationsspa
dc.subject.keywordNon-clonal chromosomal alterationsspa
dc.subject.keywordTherapy resistancespa
dc.subject.keywordTherapy responsespa
dc.titleNew insights in the cytogenetic practice: Karyotypic chaos, non-clonal chromosomal alterations and chromosomal instability in human cancer and therapy responsespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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