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Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss

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dc.creatorVatin, Magaliespa
dc.creatorBouvier, Sylviespa
dc.creatorBellazi, Lindaspa
dc.creatorMontagutelli, Xavierspa
dc.creatorLaissue, Paulspa
dc.creatorZiyyat, Ahmedspa
dc.creatorSerres, Catherinespa
dc.creatorDe Mazancourt, Philippespa
dc.creatorDieudonné, Marie-Noellespa
dc.creatorMornet, Etiennespa
dc.creatorVaiman, Danielspa
dc.creatorGris, Jean-Christophespa
dc.date.accessioned2020-05-26T00:09:52Z
dc.date.available2020-05-26T00:09:52Z
dc.date.created2014spa
dc.description.abstractFertility is a quantitative, complex character governed by a considerable number of genes. Despite clinical and scientific advances, several cases of human infertility remain unexplained. In the present study, using a positional cloning approach in a mouse model of interspecific recombinant lines, a candidate gene, ALPP, encoding the placental alkaline phosphatase, was identified as being potentially involved in recurrent spontaneous abortion. We then analyzed patients for detecting putative associations between ALPP polymorphisms, in vitro fertilization failures, and miscarriages. ALPP was sequenced in 100 controls and 100 patients affected by recurrent spontaneous abortion, from the same ethnic background. The frequency of several alleles and allelic combinations were different between recurrent spontaneous abortion and control women. One polymorphism induced a coding substitution (Ile89Leu) that was associated with a decreased risk of abortion and in vitro fertilization failure. Thereafter, the population was increased by the analysis of 92 additional controls and 612 additional patients for the coding polymorphism Ile89Leu. We finally show, by functional analysis, that the 89Leu placental alkaline phosphatase has an enhanced alkaline phosphatase activity. This study suggests that ALPP genotyping could be a strong predictor of implantation success. © 2014 American Society for Investigative Pathology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ajpath.2013.10.024
dc.identifier.issn00029440
dc.identifier.issn15252191
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24185
dc.language.isoengspa
dc.relation.citationEndPage368
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage362
dc.relation.citationTitleAmerican Journal of Pathology
dc.relation.citationVolumeVol. 184
dc.relation.ispartofAmerican Journal of Pathology, ISSN:00029440, 15252191, Vol.184, No.2 (2014); pp. 362-368spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84892141448&doi=10.1016%2fj.ajpath.2013.10.024&partnerID=40&md5=3c8aa6a4817bc01015c126fe28ab6ac9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlkaline phosphatase placenta isoenzymespa
dc.subject.keywordspontaneouseng
dc.subject.keywordAnimal modelspa
dc.subject.keywordArticlespa
dc.subject.keywordCase control studyspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEnzyme activityspa
dc.subject.keywordEnzyme polymorphismspa
dc.subject.keywordFemalespa
dc.subject.keywordFertilization in vitrospa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordIntronspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordOpen reading framespa
dc.subject.keywordPhenotypespa
dc.subject.keywordPregnancy outcomespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRecurrent abortionspa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSpontaneous abortionspa
dc.subject.keywordAbortioneng
dc.subject.keywordAlkaline phosphatasespa
dc.subject.keywordAnimalsspa
dc.subject.keywordCercopithecus aethiopsspa
dc.subject.keywordCohort studiesspa
dc.subject.keywordCos cellsspa
dc.subject.keywordFemalespa
dc.subject.keywordFertilization in vitrospa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotyping techniquesspa
dc.subject.keywordGpi-linked proteinsspa
dc.subject.keywordHumansspa
dc.subject.keywordIsoenzymesspa
dc.subject.keywordMicespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordPregnancyspa
dc.subject.keywordRecurrencespa
dc.subject.keywordReproducibility of resultsspa
dc.subject.keywordTransfectionspa
dc.titlePolymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy lossspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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