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Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein

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dc.creatorMatheus Merino, Luisa Marinaspa
dc.creatorBlair, G. Ericspa
dc.date.accessioned2020-08-06T16:20:19Z
dc.date.available2020-08-06T16:20:19Z
dc.date.created2003-10-20spa
dc.description.abstractThe myelin basic proteins (MBPs) are the major proteins of the myelin membrane. Multiple MBP mRNAs and protein isoforms are generated by alternative RNA splicing. Here we describe the isolation and characterisation of a cDNA clone encoding a 17-kDa MBP isoform from the rat (Rattus norvegicus). The isoform is a 158-amino acid protein consisting of exons 1, 3, 4, 6 and 7 of the MBP gene. RT-PCR analysis of brain mRNA showed that transcripts encoding the 17-kDa isoform were expressed at higher levels early in post-natal development, up to 7 days post-partum.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbaexp.2003.08.010
dc.identifier.issnISSN: 0167-4781
dc.identifier.issnEISSN: 1879-2634
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25960
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage53
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage47
dc.relation.citationTitleBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression
dc.relation.citationVolumeVol. 1630
dc.relation.ispartofBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, ISSN:0167-4781;EISSN: 1879-2634, Vol.1630, No.1 (2003) pp.47-53spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0167478103001842spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceBiochimica et Biophysica Acta (BBA) - Gene Structure and Expressionspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordMyelin basic proteinspa
dc.subject.keywordcDNA cloningspa
dc.subject.keywordDevelopmental expressionspa
dc.subject.keywordBrainspa
dc.subject.keywordmRNAspa
dc.subject.keywordRatspa
dc.titleIdentification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic proteinspa
dc.title.TranslatedTitleIdentificación y caracterización de un ADNc que codifica una isoforma de 17 kDa de proteína básica de mielina de rataspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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