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The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease

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dc.creatorKerr, Jonathan Rspa
dc.date.accessioned2020-05-25T23:56:04Z
dc.date.available2020-05-25T23:56:04Z
dc.date.created2016spa
dc.description.abstractHuman parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been shown to be key to the pathogenesis of the particular disease process in a significant number of cases, for example, production of rheumatoid factor in cases of B19-associated rheumatoid arthritis and production of anti-glutamic acid decarboxylase (GAD) in patients with B19-associated type 1 diabetes mellitus. B19 infection has also been associated with the development of multiple autoimmune diseases in 12 individuals. Documented mechanisms in B19-associated autoimmunity include molecular mimicry (IgG antibody to B19 proteins has been shown to cross react with a variety of recognised human autoantigens, including collagen II, keratin, angiotensin II type 1 receptor, myelin basic protein, cardiolipin, and platelet membrane glycoprotein IIb/IIIa), B19-induced apoptosis with presentation of self-antigens to T lymphocytes, and the phospholipase activity of the B19 unique VP1 protein.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1136/jclinpath-2015-203455
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22309
dc.language.isoengspa
dc.publisherBMJ Publishing Groupspa
dc.relation.citationEndPage291
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage279
dc.relation.citationTitleJournal of Clinical Pathology
dc.relation.citationVolumeVol. 69
dc.relation.ispartofJournal of Clinical Pathology, Vol.69, No.4 (2016); pp. 279-291spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84954290211&doi=10.1136%2fjclinpath-2015-203455&partnerID=40&md5=1b21a7203e1fdb6338fbc62adb6c632bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAngiotensin 1 receptorspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoantigenspa
dc.subject.keywordCardiolipinspa
dc.subject.keywordCollagen type 2spa
dc.subject.keywordFibrinogen receptorspa
dc.subject.keywordGlutamate decarboxylasespa
dc.subject.keywordGlycoprotein iibspa
dc.subject.keywordKeratinspa
dc.subject.keywordMyelin basic proteinspa
dc.subject.keywordPhospholipasespa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoantigenspa
dc.subject.keywordAplastic crisisspa
dc.subject.keywordArthralgiaspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordBrachial plexus neuropathyspa
dc.subject.keywordCerebellar ataxiaspa
dc.subject.keywordChronic fatigue syndromespa
dc.subject.keywordCranial nerve paralysisspa
dc.subject.keywordCytopeniaspa
dc.subject.keywordEnzyme activityspa
dc.subject.keywordErythema infectiosumspa
dc.subject.keywordErythrocyte lifespanspa
dc.subject.keywordFetus deathspa
dc.subject.keywordGraves diseasespa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordHeart diseasespa
dc.subject.keywordHematologic diseasespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman parvovirus b19spa
dc.subject.keywordImmune responsespa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMyalgiaspa
dc.subject.keywordMyelitisspa
dc.subject.keywordMyositisspa
dc.subject.keywordNeurologic diseasespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPersistent infectionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRashspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordT lymphocytespa
dc.subject.keywordThyroid diseasespa
dc.subject.keywordVirus transmissionspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCross reactionspa
dc.subject.keywordErythema infectiosumspa
dc.subject.keywordHuman parvovirus b19spa
dc.subject.keywordImmunologyspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordVirologyspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCross reactionsspa
dc.subject.keywordErythema infectiosumspa
dc.subject.keywordHumansspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordParvovirus b19eng
dc.titleThe role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune diseasespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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