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Antiepileptic Drugs in Treatment of Pain Caused by Diabetic Neuropathy

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dc.creatorGutierrez-Alvarez, Angela M.spa
dc.creatorBeltrán-Rodríguez, Johnnyspa
dc.creatorMoreno, Carlos B.spa
dc.date.accessioned2020-05-25T23:56:24Z
dc.date.available2020-05-25T23:56:24Z
dc.date.created2007spa
dc.description.abstractPain is frequent in diabetic neuropathy and is very hard to manage. Antiepileptic drugs have been used in treating pain for several decades. Their effectiveness has been described in different types of neuropathic pain, but when used as analgesics in painful diabetic neuropathy it still remains controversial. To clarify this effectiveness, a meta-analysis was performed to determine which antiepileptic drug had the best analgesic potential for managing pain in patients suffering from painful diabetic neuropathy. The search covered the Cochrane, MEDLINE, EMBASE, and LILACS databases, between January 1966 and September 2005. The following information was obtained from each article: criteria for diagnosing diabetic neuropathy, patients' age average, antiepileptic drug received and dose, sample size, duration of the disease and treatment follow-up, outcome measurement, evaluation of pain, and rescue medication. A combined 2.33 relative risk (95% confidence interval [CI] 1.88-2.88) was obtained; this result indicated that the antiepileptic drugs studied were effective for controlling pain in diabetic neuropathy. The corresponding necessary number to treat (NNT) values were established for evaluating which antiepileptic drug was most effective as an analgesic, according to our interests; pregabalin was shown to be the antiepileptic drug having the lowest NNT (NNT = 3.24 and 95% CI 2.12-6.81) for achieving greater than 50% analgesia in patients suffering from painful diabetic neuropathy. Antiepileptic drugs are frequently used in the specific case of diabetic neuropathy; the combined result of this meta-analysis has demonstrated their analgesic benefit. © 2007 U.S. Cancer Pain Relief Committee.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jpainsymman.2006.10.023
dc.identifier.issn8853924
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22414
dc.language.isoengspa
dc.relation.citationEndPage208
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage201
dc.relation.citationTitleJournal of Pain and Symptom Management
dc.relation.citationVolumeVol. 34
dc.relation.ispartofJournal of Pain and Symptom Management, ISSN:8853924, Vol.34, No.2 (2007); pp. 201-208spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34447625700&doi=10.1016%2fj.jpainsymman.2006.10.023&partnerID=40&md5=31fc696f8e97313b0b7bc736afbb3194spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAnticonvulsive agentspa
dc.subject.keywordCarbamazepinespa
dc.subject.keywordGabapentinspa
dc.subject.keywordLamotriginespa
dc.subject.keywordOxcarbazepinespa
dc.subject.keywordPhenytoinspa
dc.subject.keywordPregabalinspa
dc.subject.keywordTopiramatespa
dc.subject.keywordValproic acidspa
dc.subject.keywordAge distributionspa
dc.subject.keywordAnalgesic activityspa
dc.subject.keywordClinical trialspa
dc.subject.keywordCochrane libraryspa
dc.subject.keywordDiabetic neuropathyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug indicationspa
dc.subject.keywordEmbasespa
dc.subject.keywordFollow upspa
dc.subject.keywordHumanspa
dc.subject.keywordMedlinespa
dc.subject.keywordMeta analysisspa
dc.subject.keywordNeuropathic painspa
dc.subject.keywordOutcome assessmentspa
dc.subject.keywordPain assessmentspa
dc.subject.keywordReviewspa
dc.subject.keywordSample sizespa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordAnticonvulsantsspa
dc.subject.keywordDiabetic neuropathiesspa
dc.subject.keywordHumansspa
dc.subject.keywordNeuralgiaspa
dc.subject.keywordAnticonvulsantsspa
dc.subject.keywordDiabetic neuropathiesspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordNeuropathyspa
dc.subject.keywordPainspa
dc.subject.keywordRandomized controlled trialsspa
dc.subject.keywordTreatmentspa
dc.titleAntiepileptic Drugs in Treatment of Pain Caused by Diabetic Neuropathyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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