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Dynamic cerebral autoregulation reproducibility is affected by physiological variability

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dc.creatorSanders, Marit L.spa
dc.creatorElting, Jan Willem J.spa
dc.creatorPanerai, Ronney B.spa
dc.creatorAries, Marcelspa
dc.creatorBor-Seng-Shu, Edsonspa
dc.creatorCaicedo Dorado, Alexander
dc.creatorChacon, Maxspa
dc.creatorGommer, Erik D.spa
dc.creatorVan Huffel, Sabinespa
dc.creatorJara, José L.spa
dc.creatorKostoglou, Kyriakispa
dc.creatorMahdi, Adamspa
dc.creatorMarmarelis, Vasilis Z.spa
dc.creatorMitsis, Georgios D.spa
dc.creatorMüller, Martinspa
dc.creatorNikolic, Draganaspa
dc.creatorNogueira, Ricardo C.spa
dc.creatorPayne, Stephen J.spa
dc.creatorPuppo, Corinaspa
dc.creatorShin, Dae C.spa
dc.creatorSimpson, David M.spa
dc.creatorTarumi, Takashispa
dc.creatorYelicich, Bernardospa
dc.creatorZhang, Rongspa
dc.creatorClaassen, Jurgen A. H. R.spa
dc.date.accessioned2020-05-26T00:08:37Z
dc.date.available2020-05-26T00:08:37Z
dc.date.created2019spa
dc.description.abstractParameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility. In an international, multi-center study, we evaluated the influence of multiple analytical methods on the reproducibility of DCA. Fourteen participating centers analyzed repeated measurements from 75 healthy subjects, consisting of 5 min of spontaneous fluctuations in blood pressure and cerebral blood flow velocity signals, based on their usual methods of analysis. DCA methods were grouped into three broad categories, depending on output types: (1) transfer function analysis (TFA); (2) autoregulation index (ARI); and (3) correlation coefficient. Only TFA gain in the low frequency (LF) band showed good reproducibility in approximately half of the estimates of gain, defined as an intraclass correlation coefficient (ICC) of > 0.6. None of the other DCA metrics had good reproducibility. For TFA-like and ARI-like methods, ICCs were lower than values obtained with surrogate data (p less than 0.05). For TFA-like methods, ICCs were lower for the very LF band (gain 0.38 ± 0.057, phase 0.17 ± 0.13) than for LF band (gain 0.59 ± 0.078, phase 0.39 ± 0.11, p ? 0.001 for both gain and phase). For ARI-like methods, the mean ICC was 0.30 ± 0.12 and for the correlation methods 0.24 ± 0.23. Based on comparisons with ICC estimates obtained from surrogate data, we conclude that physiological variability or non-stationarity is likely to be the main reason for the poor reproducibility of DCA parameters. Copyright © 2019 Sanders, Elting, Panerai, Aries, Bor-Seng-Shu, Caicedo, Chacon, Gommer, Van Huffel, Jara, Kostoglou, Mahdi, Marmarelis, Mitsis, Müller, Nikolic, Nogueira, Payne, Puppo, Shin, Simpson, Tarumi, Yelicich, Zhang and Claassen.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fphys.2019.00865
dc.identifier.issn1664042X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24099
dc.language.isoengspa
dc.publisherFrontiers Media S.A.spa
dc.relation.citationIssueNo. JUL
dc.relation.citationTitleFrontiers in Physiology
dc.relation.citationVolumeVol. 10
dc.relation.ispartofFrontiers in Physiology, ISSN:1664042X, Vol.10, No.JUL (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85069901274&doi=10.3389%2ffphys.2019.00865&partnerID=40&md5=9fdfe759fb9f1e263eefea57c01f9385spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordAnalytic methodspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoregulationspa
dc.subject.keywordAutoregulation indexspa
dc.subject.keywordBlood flow velocityspa
dc.subject.keywordBlood pressure fluctuationspa
dc.subject.keywordBrain blood flowspa
dc.subject.keywordCorrelation coefficientspa
dc.subject.keywordDynamic cerebral autoregulationspa
dc.subject.keywordEnd tidal carbon dioxide tensionspa
dc.subject.keywordFemalespa
dc.subject.keywordFourier transformationspa
dc.subject.keywordHemodynamic parametersspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman experimentspa
dc.subject.keywordMalespa
dc.subject.keywordMean arterial pressurespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMild cognitive impairmentspa
dc.subject.keywordNormal humanspa
dc.subject.keywordPhysiological processspa
dc.subject.keywordReproducibilityspa
dc.subject.keywordTransfer function analysisspa
dc.subject.keywordAri indexspa
dc.subject.keywordCerebral blood flowspa
dc.subject.keywordCerebral hemodynamicsspa
dc.subject.keywordTranscranial dopplerspa
dc.subject.keywordTransfer function analysisspa
dc.titleDynamic cerebral autoregulation reproducibility is affected by physiological variabilityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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