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Metagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficile

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dc.creatorHerrera, Giovannyspa
dc.creatorCastañeda, Sergiospa
dc.creatorArboleda, Juan Camilospa
dc.creatorPérez-Jaramillo, Juan E.spa
dc.creatorPatarroyo, Manuel Alfonsospa
dc.creatorRamírez González, Juan Davidspa
dc.creatorMuñoz, Marinaspa
dc.date.accessioned2025-01-26T18:32:37Z
dc.date.available2025-01-26T18:32:37Z
dc.date.created2024-08-01spa
dc.date.issued2024-08-01spa
dc.descriptionClostridioides difficile may have a negative impact on gut microbiota composition in terms of diversity and abundance, thereby triggering functional changes supported by the differential presence of genes involved in significant metabolic pathways, such as short-chain fatty acids (SCFA). This work has evaluated shotgun metagenomics data regarding 48 samples from four groups classified according to diarrhea acquisition site (community- and healthcare facility-onset) and positive or negative Clostridioides difficile infection (CDI) result. The metagenomic-assembled genomes (MAGs) obtained from each sample were taxonomically assigned for preliminary comparative analysis concerning differences in composition among groups. The predicted genes involved in metabolism, transport, and signaling remained constant in microbiota membersspa
dc.descriptioncharacteristic patterns were observed in MAGs and genes involved in SCFA butyrate and acetate metabolic pathways for each study group. A decrease in genera and species, as well as relative MAG abundance with the presence of the acetate metabolism-related gene, was evident in the HCFO/- group. Increased antibiotic resistance markers (ARM) were observed in MAGs along with the genes involved in acetate metabolism. The results highlight the need to explore the role of acetate in greater depth as a potential protector of the imbalances produced by CDI, as occurs in other inflammatory intestinal diseases.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.micres.2024.127739spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/44825
dc.language.isoengspa
dc.publisherMicrobiological Researchspa
dc.relation.ispartofMicrobiological Researchspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceMicrobiological Researchspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectClostridioides difficilespa
dc.subjectMetagenome-assembled genomes (MAGs)spa
dc.subjectGut microbiota compositionspa
dc.subjectMetabolic pathwaysspa
dc.subjectDysbiosisspa
dc.titleMetagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficilespa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
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