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Functional hubs in mild cognitive impairment

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dc.creatorNavas, Adriánspa
dc.creatorPapo, Davidspa
dc.creatorBoccaletti, Stefanospa
dc.creatorDel-Pozo, F.spa
dc.creatorBajo, Ricardospa
dc.creatorMaestú, Fernandospa
dc.creatorMartínez, J. H.spa
dc.creatorGil, Pablospa
dc.creatorSendiña-Nadal, Irenespa
dc.creatorBuldú, Javier M.spa
dc.date.accessioned2020-05-26T00:11:48Z
dc.date.available2020-05-26T00:11:48Z
dc.date.created2015spa
dc.description.abstractWe investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1142/S0218127415500340
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24334
dc.language.isoengspa
dc.publisherWorld Scientific Publishing Co. Pte Ltdspa
dc.relation.citationIssueNo. 3
dc.relation.citationTitleInternational Journal of Bifurcation and Chaos
dc.relation.citationVolumeVol. 25
dc.relation.ispartofInternational Journal of Bifurcation and Chaos, Vol.25, No.3 (2015)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84928537119&doi=10.1142%2fS0218127415500340&partnerID=40&md5=08d165cfa85de2bfd833ec700526989dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBrain mappingspa
dc.subject.keywordElectric network topologyspa
dc.subject.keywordMagnetoencephalographyspa
dc.subject.keywordAlzheimer's diseasespa
dc.subject.keywordBrain networksspa
dc.subject.keywordCentralityspa
dc.subject.keywordMild cognitive impairmentsspa
dc.subject.keywordMild cognitive impairments (MCI)spa
dc.subject.keywordRandom structuresspa
dc.subject.keywordShort-term memory tasksspa
dc.subject.keywordSynchronization likelihoodsspa
dc.subject.keywordNeurodegenerative diseasesspa
dc.subject.keywordCentralityspa
dc.subject.keywordFunctional brain networksspa
dc.subject.keywordHub characterizationspa
dc.subject.keywordMild cognitive impairmentspa
dc.subject.keywordSynchronization likelihoodspa
dc.titleFunctional hubs in mild cognitive impairmentspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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