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Serum levels of dehydroepiandrosterone sulfate (DHEAS) in ocular toxoplasmosis

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dc.creatorde-la-Torre, Alejandraspa
dc.creatorRíos-Cadavid, Angela Cristinaspa
dc.creatorCardozo-García, Carlos Mariospa
dc.creatorPadilla, Leonardospa
dc.creatorGómez-Marín, Jorge Enriquespa
dc.date.accessioned2020-08-06T16:21:39Z
dc.date.available2020-08-06T16:21:39Z
dc.date.created2012-02spa
dc.description.abstractOcular toxoplasmosis is the most common infectious cause of retinochoroidal inflammation in immunocompetent individuals and is one of the most important causes of visual damage in some countries.1 Thus, in Colombia, it is estimated that 6% of the population has retinochoroidal scars after a non congenital infection and 20% of these persons have reduced visual capacity.2 Recurrent retinochoroiditis is a typical characteristic of ocular toxoplasmosis and the factors related to this remain to be discovered.3 In a field study in Brazil, a relation between puberty, gender and apparition of new lesions in ocular toxoplasmosis was described.4 A hormonal factor triggering recurrences has been evocated but the precise hormones linked to these events have not been studied. In recent years there has been strong speculation that puberty-related hormones, dehydroepiandrosterone (DHEA) in particular, might play some role in inducing resistance during Schistosoma, HIV and malaria infections.5, 6, 7 DHEA is one of the steroid hormones produced by the adrenal cortex and is found mostly in its sulfate form, DHEA sulfate (DHEAS); it is converted to DHEA by DHEA sulfatase.8 The secretion of DHEAS is high just before birth and again at puberty, and the maximum concentration is reached at around 20 to 30 years of age, followed by a progressive decline with age. DHEAS is implicated in age-related changes in the immune system and has been associated with disease susceptibility.9 To our knowledge, no report has been made of the DHEAS levels during human toxoplasmosis.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jmii.2011.09.003
dc.identifier.issnISSN: 1684-1182
dc.identifier.issnEISSN: 1995-9133
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26422
dc.language.isoengspa
dc.publisherTaiwan Society of Microbiologyspa
dc.publisherElsevierspa
dc.relation.citationEndPage68
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage65
dc.relation.citationTitleJournal of Microbiology, Immunology and Infection
dc.relation.citationVolumeVol. 45
dc.relation.ispartofJournal of Microbiology, Immunology and Infection, ISSN: 1684-1182;EISSN: 1995-9133, Vol.45, No.1 (2012); pp.65-68spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1684118211001587spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceJournal of Microbiology, Immunology and Infectionspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordChorioretinitisspa
dc.subject.keywordDehydroepiandrostenione hormonesspa
dc.subject.keywordToxoplasmosisspa
dc.titleSerum levels of dehydroepiandrosterone sulfate (DHEAS) in ocular toxoplasmosisspa
dc.title.TranslatedTitleNiveles séricos de sulfato de dehidroepiandrosterona (DHEAS) en toxoplasmosis ocularspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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