Ítem
Acceso Abierto

Familial aggregation and segregation analysis in families presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome

Mostrar el registro sencillo de la publicación
dc.creatorCastiblanco, John
dc.creatorSarmiento Monroy, Juan Camilo
dc.creatorMantilla, Ruben Dario
dc.creatorRojas-Villarraga, Adriana
dc.creatorAnaya, Juan-Manuel
dc.creator.googleCastiblanco, Johnspa
dc.creator.googleSarmiento-Monroy, Juan Camilospa
dc.creator.googleMantilla, Ruben Dariospa
dc.creator.googleRojas-Villarraga, Adrianaspa
dc.creator.googleAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-07T10:06:46Z
dc.date.available2020-05-07T10:06:46Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractStudies documenting increased risk of developing autoimmune diseases (ADs) have shown that these conditions share several immunogenetic mechanisms (i.e., the autoimmune tautology). This report explored familial aggregation and segregation of AD, polyautoimmunity, and multiple autoimmune syndrome (MAS) in 210 families. Familial aggregation was examined for first-degree relatives. Segregation analysis was implemented as in S.A.G.E. release 6.3. Data showed differences between late- and early-onset families regarding their age, age of onset, and sex. Familial aggregation of AD in late- and early-onset families was observed. For polyautoimmunity as a trait, only aggregation was observed between sibling pairs in late-onset families. No aggregation was observed for MAS. Segregation analyses for AD suggested major gene(s) with no clear discernible classical known Mendelian transmission in late-onset families, while for polyautoimmunity and MAS no model was implied. Data suggest that polyautoimmunity and MAS are not independent traits and that gender, age, and age of onset are interrelated factors influencing autoimmunity. © 2015 John Castiblanco et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2015/572353
dc.identifier.issn2314-8861
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21887
dc.language.isoengspa
dc.relation.citationTitleJournal of Immunology Research
dc.relation.citationVolumeVol. 2015
dc.relation.ispartofJournal of Immunology Research, ISSN: 2314-8861 Vol. 2015, (2015)spa
dc.relation.urihttps://www.hindawi.com/journals/jir/2015/572353/spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcCiencias médicas, Medicinaspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordadultspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordAgeeng
dc.subject.keywordAutoimmunityeng
dc.subject.keywordCodominanceeng
dc.subject.keywordColombiaeng
dc.subject.keywordDisease transmissioneng
dc.subject.keywordFamilial aggregationeng
dc.subject.keywordFirst degree relativeeng
dc.subject.keywordGenetic analysiseng
dc.subject.keywordMajor clinical studyeng
dc.subject.keywordMajor geneeng
dc.subject.keywordMendelian transmissioneng
dc.subject.keywordMaleeng
dc.subject.keywordMultiple Autoimmune Syndromeeng
dc.subject.keywordOnset Ageeng
dc.subject.keywordPedigreeeng
dc.subject.keywordPolyautoimmunityeng
dc.titleFamilial aggregation and segregation analysis in families presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Familial_Aggregation_and_Segregation_Analysis_in_Families_Presenting_Autoimmunity_Polyautoimmunity_and_Multiple_Autoimmune_Syndrome.pdf
Tamaño:
1.3 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos