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Long-term dynamics of SARS-CoV-2 immunity in a university hospital in Colombia: A cohort study

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dc.creatorQuintero, Julianaspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorGonzález-Uribe, Catalinaspa
dc.creatorMartínez, Oscarspa
dc.creatorMoreno, Sergiospa
dc.creatorFajardo, Nataliaspa
dc.creatorAcosta Ampudia, Yenyspa
dc.creatorCaballero, Nohemispa
dc.creatorMonsalve, Diana M.spa
dc.date.accessioned2025-07-21T16:48:56Z
dc.date.available2025-07-21T16:48:56Z
dc.date.created2025-06-01spa
dc.date.issued2025-06-01spa
dc.description.abstractObjectives: This prospective cohort study aimed to estimate the natural, vaccine-induced, and hybrid immunity to SARS-CoV-2, alongside the immunogenicity of the messenger RNA (mRNA)?1273 booster after the BNT162b2 primary series in health care workers in Colombia. Methods: Immunoglobulin (Ig) G, IgA, and neutralizing antibodies were measured in 110 individuals with SARSCoV-2 infection or a BNT162b2 primary series. Humoral responses and related factors were explored in a subgroup (n = 36) that received a BNT162b2 primary series, followed by a mRNA-1273 booster (2BNT162b2 + 1mRNA1273), and T-cell responses were evaluated in a subgroup of them (n = 16). Results: For natural immunity, IgG and IgA peaked within 3 months, declining gradually but remaining detectable up to 283 days post-infection. Neutralizing antibody inhibition post-infection was below positive range (?35%) but exceeded 97% in vaccine-induced and hybrid immunity groups. After 2BNT162b2 + 1mRNA-1273, IgG peaked 3-4 months post-booster, gradually declining but remaining positive over 10 months, with IgA and neutralizing antibodies stable. Age and blood group were related to IgG response, whereas obesity and blood type were related to IgA response post-booster. Autoimmunity and blood type B were associated with lower neutralizing antibody inhibition. There were no differences in T-cell responses according to previous infection. Conclusions: These findings provide long-term insights into the immunity against SARS-CoV-2 and the immunogenicity of mRNA vaccines.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijregi.2025.100641spa
dc.identifier.issn2772-7076spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46086
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.ispartofInternational Society for Infectious Diseases. IJID Regions Volume 15, June 2025spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2772707625000761?via%3Dihubspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceInternational Society for Infectious Diseases. IJID Regionsspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordSARS-CoV-eng
dc.subject.keywordHealth care workerseng
dc.subject.keywordmRNA vaccineseng
dc.subject.keywordHumoral responseeng
dc.subject.keywordT-cell responseeng
dc.subject.keywordImmunogenicityeng
dc.titleLong-term dynamics of SARS-CoV-2 immunity in a university hospital in Colombia: A cohort studyspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de Investigaciónspa
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