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Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates

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dc.creatorCatano G.spa
dc.creatorChykarenko Z.A.spa
dc.creatorMangano A.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorHe W.spa
dc.creatorSmith A.spa
dc.creatorBologna R.spa
dc.creatorSen L.spa
dc.creatorClark R.A.spa
dc.creatorLloyd A.spa
dc.creatorShostakovich-Koretskaya L.spa
dc.creatorAhuja S.K.spa
dc.date.accessioned2020-05-25T23:56:15Z
dc.date.available2020-05-25T23:56:15Z
dc.date.created2011spa
dc.description.abstractWe used cutaneous delayed-type hypersensitivity responses, a powerful in vivo measure of cell-mediated immunity, to evaluate the relationships among cell-mediated immunity, AIDS, and polymorphisms in CCR5, the HIV-1 coreceptor. There was high concordance between CCR5 polymorphisms and haplotype pairs that influenced delayed-type hypersensitivity responses in healthy persons and HIV disease progression. In the cohorts examined, CCR5 genotypes containing -2459G/G (HHA/HHA, HHA/HHC, HHC/HHC) or -2459A/A (HHE/HHE) associated with salutary or detrimental delayed-type hypersensitivity and AIDS phenotypes, respectively. Accordingly, the CCR5-D32 allele, when paired with non-?32-bearing haplotypes that correlate with low (HHA, HHC) versus high (HHE) CCR5 transcriptional activity, associates with disease retardation or acceleration, respectively. Thus, the associations of CCR5-?32 heterozygosity partly reflect the effect of the non-?32 haplotype in a background of CCR5 haploinsufficiency. The correlations of increased delayed-type hypersensitivity with -2459G/G-containing CCR5 genotypes, reduced CCR5 expression, decreased viral replication, and disease retardation suggest that CCR5 may influence HIV infection and AIDS, at least in part, through effects on cell-mediated immunity. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jiq023
dc.identifier.issn00221899
dc.identifier.issn15376613
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22375
dc.language.isoengspa
dc.relation.citationEndPage272
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage263
dc.relation.citationTitleJournal of Infectious Diseases
dc.relation.citationVolumeVol. 203
dc.relation.ispartofJournal of Infectious Diseases, ISSN:00221899, 15376613, Vol.203, No.2 (2011); pp. 263-272spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79851475866&doi=10.1093%2finfdis%2fjiq023&partnerID=40&md5=43c0b3b7971702d3bf33fc34343f1805spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordChemokine receptor CCR5spa
dc.subject.keywordGeneticeng
dc.subject.keywordDelayedeng
dc.subject.keywordCellulareng
dc.subject.keywordCCR5eng
dc.subject.keywordVirus receptorspa
dc.subject.keywordAcquired immune deficiency syndromespa
dc.subject.keywordAdultspa
dc.subject.keywordAIDS patientspa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordCellular immunityspa
dc.subject.keywordCohort analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDelayed hypersensitivityspa
dc.subject.keywordDisease coursespa
dc.subject.keywordFemalespa
dc.subject.keywordGene expressionspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic transcriptionspa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordHeterozygosityspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordHuman immunodeficiency virus 1 infectionspa
dc.subject.keywordHuman immunodeficiency virus infected patientspa
dc.subject.keywordImmunoregulationspa
dc.subject.keywordIn vivo studyspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPhenotypespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordVirus immunityspa
dc.subject.keywordVirus pathogenesisspa
dc.subject.keywordVirus replicationspa
dc.subject.keywordAdultspa
dc.subject.keywordDisease Progressionspa
dc.subject.keywordFemalespa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHIV-1spa
dc.subject.keywordHumansspa
dc.subject.keywordHypersensitivityeng
dc.subject.keywordImmunityeng
dc.subject.keywordMalespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordReceptorseng
dc.titleConcordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression ratesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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