The Autoimmune Tautology: An In Silico Approach

Cifuentes, Ricardo; Restrepo-Montoya, Daniel; Anaya, Juan-Manuel

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The Autoimmune Tautology: An In Silico Approach

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dc.audience	Comunidad Rosarista	spa
dc.creator	Cifuentes, Ricardo
dc.creator	Restrepo-Montoya, Daniel
dc.creator	Anaya, Juan-Manuel
dc.creator.google	Cifuentes, Ricardo A.
dc.creator.google	Restrepo-Montoya, Daniel
dc.creator.google	Anaya, Juan-Manuel
dc.date.accessioned	2014-08-11T20:31:28Z
dc.date.available	2014-08-11T20:31:28Z
dc.date.created	2012
dc.date.issued	2012
dc.description.abstract	There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published. Thus, our aim was to determine the main shared genes and to what extent they contribute to building clusters of AIDs. We combined a text-mining approach to build clusters of genetic concept profiles (GCPs) from the literature in MedLine with knowledge of protein-protein interactions to confirm if genes in GCP encode proteins that truly interact. We found three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions. After projecting the AIDs on a plane, two clusters could be discerned: Sjögren’s syndrome—systemic lupus erythematosus, and autoimmune thyroid disease—type1 diabetes—rheumatoid arthritis. Our results support the common origin of AIDs and the role of genes involved in apoptosis such as CTLA4, FASLG, and IL10.	eng
dc.format.medium	Recurso electrónico	spa
dc.format.mimetype	application/pdf
dc.format.tipo	Documento	spa
dc.identifier.issn	ISSN:2090-0430
dc.identifier.uri	http://repository.urosario.edu.co/handle/10336/8778
dc.language.iso	eng
dc.publisher	Universidad del Rosario	spa
dc.relation.citationTitle	Autoimmune Diseases
dc.relation.ispartof	Autoimmune Diseases, ISSN 2090-04-30, 2012	spa
dc.rights.accesRights	info:eu-repo/semantics/openAccess
dc.rights.acceso	Abierto (Texto completo)	spa
dc.rights.licencia	EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.	spa
dc.source.instname	instname:Universidad del Rosario	spa
dc.source.reponame	reponame:Repositorio Institucional EdocUR	spa
dc.subject.ddc	Enfermedades
dc.subject.decs	Enfermedades autoinmunes	spa
dc.subject.decs	Inmunología	spa
dc.subject.decs	Sida	spa
dc.subject.decs	Diabetes	spa
dc.title	The Autoimmune Tautology: An In Silico Approach	spa
dc.type	article	eng
dc.type.hasVersion	info:eu-repo/semantics/acceptedVersion
dc.type.spa	Artículo	spa