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Genetics and autoantibodies

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dc.creatorPerricone, Carlospa
dc.creatorAgmon-Levin, Nancyspa
dc.creatorCeccarelli, Fulviaspa
dc.creatorValesini, Guidospa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-26T00:11:01Z
dc.date.available2020-05-26T00:11:01Z
dc.date.created2013spa
dc.description.abstractAutoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development. Several polymorphic genes contribute to the development of ADs. Furthermore, age and gender play a major role by influencing hormone levels that can represent the fulcrum unbalancing from susceptibility to protection. Evidences suggest that while all these steps occur, the susceptible individual develops autoantibodies over a long time lapse. Such autoantibody production is genetically determined and finally, their presence seems to determine the clinical presentation of ADs. The genetic predisposition to the developments of autoantibodies and toward the disease process may overlap. The unveiling of these mechanisms could allow not only to treat but also to prevent the development of autoimmune diseases. © 2013 Springer Science+Business Media New York.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12026-013-8396-9
dc.identifier.issn0257277X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24276
dc.language.isoengspa
dc.relation.citationEndPage219
dc.relation.citationIssueNo. 43892
dc.relation.citationStartPage206
dc.relation.citationTitleImmunologic Research
dc.relation.citationVolumeVol. 56
dc.relation.ispartofImmunologic Research, ISSN:0257277X, Vol.56, No.43892 (2013); pp. 206-219spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84879550144&doi=10.1007%2fs12026-013-8396-9&partnerID=40&md5=e5841caef4491e10540df2864a564012spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoimmune regulator proteinspa
dc.subject.keywordgeneticeng
dc.subject.keywordDeoxyribonuclease ispa
dc.subject.keywordDna methyltransferase 1spa
dc.subject.keywordHla dqb1 antigenspa
dc.subject.keywordHla drb1 antigenspa
dc.subject.keywordInterferon regulatory factor 7spa
dc.subject.keywordInterleukin 10spa
dc.subject.keywordMitochondrion antibodyspa
dc.subject.keywordNeutrophil cytoplasmic antibodyspa
dc.subject.keywordPhospholipid antibodyspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordStat4 proteinspa
dc.subject.keywordThyrotropin receptor antibodyspa
dc.subject.keywordTransforming growth factor betaspa
dc.subject.keywordTumor necrosis factor receptor associated factor 1spa
dc.subject.keywordVitamin dspa
dc.subject.keywordAgespa
dc.subject.keywordAllelespa
dc.subject.keywordAntigen presentationspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordAutoimmune thyroiditisspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordB lymphocytespa
dc.subject.keywordCd8+ t lymphocytespa
dc.subject.keywordDermatomyositisspa
dc.subject.keywordDietspa
dc.subject.keywordDisease coursespa
dc.subject.keywordDna polymorphismspa
dc.subject.keywordEnteritisspa
dc.subject.keywordEpstein barr virusspa
dc.subject.keywordEpstein barr virus infectionspa
dc.subject.keywordGenderspa
dc.subject.keywordGene interactionspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHabitspa
dc.subject.keywordHla systemspa
dc.subject.keywordHormone determinationspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman genomespa
dc.subject.keywordHypertensionspa
dc.subject.keywordHypothesisspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmune systemspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordImmunoglobulin a deficiencyspa
dc.subject.keywordImmunological tolerancespa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordJuvenile dermatomyositisspa
dc.subject.keywordLymphocyte differentiationspa
dc.subject.keywordLymphocyte proliferationspa
dc.subject.keywordMononucleosisspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPemphigusspa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSaccharomyces cerevisiaespa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSmokespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordT lymphocytespa
dc.subject.keywordUlcerative colitisspa
dc.subject.keywordVasculitisspa
dc.subject.keywordVitamin blood levelspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordGene-environment interactionspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHla antigensspa
dc.subject.keywordHomeostasisspa
dc.subject.keywordHormonesspa
dc.subject.keywordHumansspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSelf tolerancespa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGeneticspa
dc.subject.keywordPolymorphismsspa
dc.subject.keywordSaccharomyces cerevisiaespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleGenetics and autoantibodiesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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