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Plasmodium vivax merozoite surface protein 8 cloning, expression, and characterisation

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dc.creatorPérez-Leal, Óscarspa
dc.creatorSierra, Adriana Y.spa
dc.creatorBarrero, Carlos A.spa
dc.creatorMoncada, Camilospa
dc.creatorMartínez Rángel, Diana Pilarspa
dc.creatorCortés, Jimenaspa
dc.creatorLópez, Yolandaspa
dc.creatorTorres, Elizabethspa
dc.creatorSalazar, Luz M.spa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-08-06T16:20:16Z
dc.date.available2020-08-06T16:20:16Z
dc.date.created2004-11-26spa
dc.description.abstractPlasmodium vivax, one of the four parasite species causing malaria in humans, is the most widespread throughout the world, leading to nearly 80 million cases per year, mainly in Latin-America and Asia. An open reading frame encoding the Plasmodium falciparum merozoite surface protein 8 P. vivax homologue has been identified in the present study by screening the current data obtained from this parasite’s partially sequenced genome. This new protein contains 487 amino-acids, two epidermal growth factor like domains, hydrophobic regions at the N- and C-termini compatible with a signal peptide, and a glycosylphosphatidylinositol anchor site, respectively. This gene’s transcription and its encoded protein expression have been assessed, as well as its recognition by P. vivax-infected patients’ sera. Based on this recognition, and a previous study showing that mice immunised with the Plasmodium yoelii homologous protein were protected, we consider the PvMSP8 a good candidate to be included in a multi-stage multi-antigen P. vivax vaccine.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2004.09.202
dc.identifier.issnISSN: 0006-291X
dc.identifier.issnEISSN: 1090-2104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25941
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage1399
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage1393
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 324
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.324, No.4 (2004); pp.1393-1399spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0006291X04022429spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceBiochemical and Biophysical Research Communicationsspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordMSP8spa
dc.subject.keywordVaccine candidatespa
dc.subject.keywordSurface proteinspa
dc.titlePlasmodium vivax merozoite surface protein 8 cloning, expression, and characterisationspa
dc.title.TranslatedTitlePlasmodium vivax merozoite surface protein 8 clonación, expresión y caracterizaciónspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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