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The Long Pentraxin 3 and Its Role in Autoimmunity

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dc.creatorOrtega-Hernandez, Oscar-Danilospa
dc.creatorBassi, Nicolaspa
dc.creatorShoenfeld, Yehudaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:00:58Z
dc.date.available2020-05-26T00:00:58Z
dc.date.created2009spa
dc.description.abstractObjectives: To review the physiological and physiopathological roles of pentraxin 3 (PTX3), focusing on autoimmunity and vascular pathology. Methods: A systematic literature review using the keywords 'pentraxin 3,' 'innate immunity,' 'apoptosis,' 'autoimmunity,' and 'endothelial dysfunction' from 1990 to 2007 was performed. All relevant articles and pertinent secondary references in English were reviewed. Results: PTX3 has a large number of multiple functions in different contexts. PTX3 plays an important role in innate immunity, inflammation, vascular integrity, fertility, pregnancy, and also in the central nervous system. In innate immunity, its normal function is to increase the immune response to selected pathogens while also exerting control over potential autoimmune reactions. It maintains a tightly homeostatic equilibrium in the local immune microenvironment by avoiding an exaggerated immune response and controlling peripheral tolerance to self-antigens. In contrast, in some autoimmune diseases, PTX3 appears to be involved in the development of autoimmune phenomena. A possible explanation for these apparent paradoxical functions may be related to the highly polymorphic PTX3 gene. Conclusion: PTX3 is physiologically a protective molecule. However, in several autoimmune diseases PTX3 appears to facilitate the development of autoimmunity. The PTX3 gene could influence the development of autoimmune reactions and vascular involvement in human pathology. © 2008 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.semarthrit.2008.03.006
dc.identifier.issn490172
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23294
dc.language.isoengspa
dc.relation.citationEndPage54
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage38
dc.relation.citationTitleSeminars in Arthritis and Rheumatism
dc.relation.citationVolumeVol. 39
dc.relation.ispartofSeminars in Arthritis and Rheumatism, ISSN:490172, Vol.39, No.1 (2009); pp. 38-54spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-67651062322&doi=10.1016%2fj.semarthrit.2008.03.006&partnerID=40&md5=e606e9962511d2d9b2e3ba7823405fccspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCytokinespa
dc.subject.keywordPentraxin 3spa
dc.subject.keywordinnateeng
dc.subject.keywordvasculareng
dc.subject.keywordAmino terminal sequencespa
dc.subject.keywordAntigen antibody reactionspa
dc.subject.keywordAntigen presentationspa
dc.subject.keywordApoptosisspa
dc.subject.keywordArticlespa
dc.subject.keywordAtherosclerosisspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCarboxy terminal sequencespa
dc.subject.keywordCardiovascular inflammationspa
dc.subject.keywordCentral nervous systemspa
dc.subject.keywordDisease activityspa
dc.subject.keywordDisease associationspa
dc.subject.keywordDisease coursespa
dc.subject.keywordDisease exacerbationspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordDna polymorphismspa
dc.subject.keywordEndothelial dysfunctionspa
dc.subject.keywordFertilityspa
dc.subject.keywordGene functionspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunological tolerancespa
dc.subject.keywordImmunopathogenesisspa
dc.subject.keywordImmunoregulationspa
dc.subject.keywordInflammationspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordMolecular biologyspa
dc.subject.keywordMolecular weightspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPregnancyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordPromoter regionspa
dc.subject.keywordProtein deficiencyspa
dc.subject.keywordProtein domainspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProtein modificationspa
dc.subject.keywordProtein secretionspa
dc.subject.keywordProtein stabilityspa
dc.subject.keywordProtein structurespa
dc.subject.keywordRna sequencespa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordVascular diseasespa
dc.subject.keywordVascular endotheliumspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordC-reactive proteinspa
dc.subject.keywordEndotheliumeng
dc.subject.keywordHumansspa
dc.subject.keywordImmunityeng
dc.subject.keywordSerum amyloid p-componentspa
dc.subject.keywordVascular diseasesspa
dc.subject.keywordApoptosisspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordEndothelial dysfunctionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordPentraxin 3spa
dc.titleThe Long Pentraxin 3 and Its Role in Autoimmunityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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