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Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology

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dc.creatorSany, J.spa
dc.creatorJorgensen, CH.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorDidry, Cspa
dc.creatorAndary, M.spa
dc.creatorSerre, I.spa
dc.creatorBaldet, P.spa
dc.date.accessioned2020-08-19T14:41:29Z
dc.date.available2020-08-19T14:41:29Z
dc.date.created1992spa
dc.description.abstractPrimary agammaglobulinemia is a rare disorder which is associated with articular symptoms in 11% of patients. Septic arthritis may occur, but often patients complain of chronic oligoarthritis and have a clinical presentation similar to rheumatoid arthritis. We report 2 cases of primary agammaglobulinemia in adults, associated with non-erosive chronic arthritis. Peripheral blood lymphocyte phenotyping showed a predominance of CD8 lymphocytes with a CD4/CD8 ratio < 1. We did not find any abnormalities in cellular immunity. A histological study of the synovium showed chronic synovitis with perivascular CD8 lymphocyte infiltrates. Intravenous infusion of immunoglobulins resulted in a dramatic improvement in the arthritis in both cases. In one patient we noticed a decrease in CD8 lymphocytosis. These results suggest that CD8 lymphocytes are involved in the pathogenesis of the arthritis associated with agammaglobulinemia.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 0392-856X
dc.identifier.issnEISSN: 1593-098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27247
dc.language.isoengspa
dc.publisherEurope PMCspa
dc.relation.citationEndPage69
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage65
dc.relation.citationTitleClinical and Experimental Rheumatology
dc.relation.citationVolumeVol. 11
dc.relation.ispartofClinical and Experimental Rheumatology, ISSN: 0392-856X; EISSN: 1593-098X , Vol.11, No.1 (1992); pp. 65-69spa
dc.relation.urihttps://europepmc.org/article/med/8453802spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceClinical and Experimental Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPrimary agammaglobulinemiaspa
dc.subject.keywordSeptic arthritisspa
dc.titleArthritis associated with primary agammaglobulinemia: New clues to its immunopathologyspa
dc.title.TranslatedTitleArtritis asociada a agammaglobulinemia primaria: nuevas pistas sobre su inmunopatologíaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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