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A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort

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dc.creatorYu, C.
dc.creatorArcos-Burgos, Mauricio
dc.creatorLicinio, Julio
dc.creatorWong, M-L
dc.creator.googleYu, C.spa
dc.creator.googleArcos-Burgos, M.spa
dc.creator.googleLicinio, J.spa
dc.creator.googleWong, M.-L.spa
dc.date.accessioned2020-04-02T18:21:30Z
dc.date.available2020-04-02T18:21:30Z
dc.date.created2017
dc.date.issued2017
dc.description.abstractIdentifying data-driven subtypes of major depressive disorder (MDD) is an important topic of psychiatric research. Currently, MDD subtypes are based on clinically defined depression symptom patterns. Although a few data-driven attempts have been made to identify more homogenous subgroups within MDD, other studies have not focused on using human genetic data for MDD subtyping. Here we used a computational strategy to identify MDD subtypes based on single-nucleotide polymorphism genotyping data from MDD cases and controls using Hamming distance and cluster analysis. We examined a cohort of Mexican-American participants from Los Angeles, including MDD patients (n=203) and healthy controls (n=196). The results in cluster trees indicate that a significant latent subtype exists in the Mexican-American MDD group. The individuals in this hidden subtype have increased common genetic substrates related to major depression and they also have more anxiety and less middle insomnia, depersonalization and derealisation, and paranoid symptoms. Advances in this line of research to validate this strategy in other patient groups of different ethnicities will have the potential to eventually be translated to clinical practice, with the tantalising possibility that in the future it may be possible to refine MDD diagnosis based on genetic data. © 2017 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/tp.2017.102
dc.identifier.issn2158-3188
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21424
dc.language.isoengspa
dc.relation.citationIssueNo. 5
dc.relation.citationTitleTranslational Psychiatry
dc.relation.citationVolumeVol. 7
dc.relation.ispartofTranslational Psychiatry, ISSN: 2158-3188 Vol. 7, No. 5 (2017)spa
dc.relation.urihttps://www.nature.com/articles/tp2017102spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectagedspa
dc.subjectanxietyspa
dc.subjectCaliforniaspa
dc.subjectclinical practicespa
dc.subjectcohort analysisspa
dc.subjectdepersonalizationspa
dc.subjectethnicityspa
dc.subjectinsomniaspa
dc.subjectmajor clinical studyspa
dc.subjectmajor depressionspa
dc.subjectmalespa
dc.subjectMexican Americanspa
dc.subjectparanoiaspa
dc.subjectsingle nucleotide polymorphismspa
dc.subjectwhole exome sequencingspa
dc.subjectanxiety disorderspa
dc.subjectclassificationspa
dc.subjectclinical trialspa
dc.subjectcluster analysisspa
dc.subjectdepersonalizationspa
dc.subjectethnologyspa
dc.subjectexomespa
dc.subjectgeneticsspa
dc.subjectgenotypespa
dc.subjectinsomniaspa
dc.subjectmajor depressionspa
dc.subjectparanoiaspa
dc.subjectsingle nucleotide polymorphismspa
dc.subjectyoung adultspa
dc.subjectAgedspa
dc.subjectAnxiety Disordersspa
dc.subjectCluster Analysisspa
dc.subjectDepersonalizationspa
dc.subjectExomespa
dc.subjectGenotypespa
dc.subjectLos Angelesspa
dc.subjectMalespa
dc.subjectMexican Americansspa
dc.subjectParanoid Behaviorspa
dc.subjectSleep Initiation and Maintenance Disordersspa
dc.subjectYoung Adultspa
dc.subjectDepresiónspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordadultspa
dc.subject.keywordSingle Nucleotideeng
dc.subject.keywordArticlespa
dc.subject.keywordcontrolled studyspa
dc.subject.keywordfemalespa
dc.subject.keywordhumanspa
dc.subject.keywordmiddle agedspa
dc.subject.keywordAdultspa
dc.subject.keywordDepressive Disordereng
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordPolymorphismeng
dc.subject.lembDrepresiónspa
dc.subject.lembTrastorno depresivospa
dc.titleA latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohortspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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