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Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization

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dc.creatorBermudez, Adriana
dc.creatorReyes, Claudiaspa
dc.creatorGuzmán, Fannyspa
dc.creatorVanegas, Magnoliaspa
dc.creatorRosas, Jaiverspa
dc.creatorAmador, Robertospa
dc.creatorRodríguez, Raulspa
dc.creatorPatarroyo, Manuel A.
dc.creatorPatarroyo, Manuel Elkinspa
dc.date.accessioned2020-08-19T14:40:44Z
dc.date.available2020-08-19T14:40:44Z
dc.date.created2007-05-30spa
dc.description.abstractThe SPf66 synthetic malaria vaccine, developed and obtained almost 2 decades ago, represents the first approach towards developing a multi-antigenic, multi-stage synthetic malarial vaccine composed of subunits derived from different Plasmodium falciparum stage proteins. It is shown here that batches 03, 04, 05, 06, 07, 08, 09, 10, 11, 12, 13, 14, 15 and 16 produced from a few milligrams to kilogram amounts and used in assays on monkeys and humans showed high reproducibility in physicochemical analysis. 1H NMR two-dimensional studies also revealed high similarity, even in non-oxidized batches. Reproducibility was also high, especially in preclinical studies carried out on Aotus, clinical trials Phase I, IIa and IIb and field-studies carried out in La Tola, Rio Rosario (Colombia), Majadas (Venezuela), La Te (Ecuador), Ifakara (Tanzania) in which there was high antibody titer production, having similar population distribution when done with different batches.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2007.03.016
dc.identifier.issnISSN: 0264-410X
dc.identifier.issnEISSN: 1873-2518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27007
dc.language.isoengspa
dc.publisherThe Japanese Society for Vaccinologyspa
dc.publisherElsevierspa
dc.relation.citationEndPage4501
dc.relation.citationIssueNo. 22
dc.relation.citationStartPage4487
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 25
dc.relation.ispartofVaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.25 , No.22 (2007); pp. 4487-4501 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X07003106?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceVaccinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSPf66spa
dc.subject.keywordMalariaspa
dc.subject.keywordMALDI-TOFspa
dc.subject.keywordDCspa
dc.subject.keywordHPLCspa
dc.subject.keywordNMRspa
dc.subject.keywordImmunogenicityspa
dc.titleSynthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterizationspa
dc.title.TranslatedTitleActualización de la vacuna sintética: aplicación de las lecciones aprendidas de la reciente caracterización fisicoquímica, estructural e inmunológica de la vacuna contra la malaria SPf66spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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